Abstract：
:Five rare sesquiterpene lactone dimers, vlasouliolides E-I, were isolated from Vladimiria souliei. Their chemical structures were elucidated by spectroscopic analysis. Furthermore, 2 and 4 were unambiguously confirmed by Cu-Kα X-ray crystallographic analysis. Compounds 1, 2, 4 and 5 exhibited significant anti-inflammatory activity against LPS-induced NO production in RAW 264.7 cells with IC50 values of 1.88, 4.89, 7.24 and 2.46μM, respectively. Additionally, compounds 1 and 2 were revealed with potent inhibitory activity of the phosphorylation progress of NF-κB P65.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Wu ZL,Wang JX,Chen LP,Dong HY,Li HL,Zhang WDdoi
10.1016/j.fitote.2018.01.002subject
Has Abstractpub_date
2018-03-01 00:00:00pages
117-122eissn
0367-326Xissn
1873-6971pii
S0367-326X(17)31741-0journal_volume
125pub_type
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