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2-(2-Phenylethyl)chromone derivatives in artificial agarwood from Aquilaria sinensis.

Abstract：

:Seven new 2-(2-phenylethyl)chromone derivatives (1-7) including a chlorinated one (4), together with eight known ones (8-15), were isolated from the EtOAc extract of artificial agarwood originating from Aquilaria sinensis (Lour.) Gilg. All structures including the absolute configurations were unambiguously elucidated by spectroscopic (NMR, UV, IR, MS) methods, Mosher's method, and comparison with reported data in the literatures. Among those, compounds 8, 12, and 14 exhibited significant inhibition against α-glucosidase in vitro with IC50 values of 0.15, 0.05, and 0.09 mM, respectively (with acarbose as the positive control; IC50: 0.98 mM). In addition, compounds 3, 9, 11, and 14 showed weak inhibitory activity against AChE; and compounds 12 and 13 displayed weak cytotoxicity against human gastric cell line (SGC-7901) among three types of tested human cancer cell lines (BEL-7402, K562, and SGC-7901).

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Liao G,Mei WL,Dong WH,Li W,Wang P,Kong FD,Gai CJ,Song XQ,Dai HF

doi

10.1016/j.fitote.2016.01.011

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

38-43

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(16)30011-9

journal_volume

110

pub_type

杂志文章

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