Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet.

Abstract:

:Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of 0.25-1mg/ml. It inhibited hydrolysis of about 83.2% of triolein at about 1mg/ml of PDG. However, PTG showed no inhibitory activity. Therefore, anti-obesity activity of PDG was evaluated in mice fed a high-fat diet. The results demonstrated that PDG was effective in preventing and healing obesity, fatty liver and hypertriglyceridemia in mice fed with a high-fat diet.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Liu R,Zhang J,Liu W,Kimura Y,Zheng Y

doi

10.1016/j.fitote.2010.07.002

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1079-87

issue

8

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(10)00163-2

journal_volume

81

pub_type

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