Abstract:
:Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of 0.25-1mg/ml. It inhibited hydrolysis of about 83.2% of triolein at about 1mg/ml of PDG. However, PTG showed no inhibitory activity. Therefore, anti-obesity activity of PDG was evaluated in mice fed a high-fat diet. The results demonstrated that PDG was effective in preventing and healing obesity, fatty liver and hypertriglyceridemia in mice fed with a high-fat diet.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Liu R,Zhang J,Liu W,Kimura Y,Zheng Ydoi
10.1016/j.fitote.2010.07.002subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1079-87issue
8eissn
0367-326Xissn
1873-6971pii
S0367-326X(10)00163-2journal_volume
81pub_type
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