Abstract：
:Seven new lignans, cleistonkinins A- E (1-5), cleistonkisides A and B (6-7) were isolated from the fruits of Cleistanthus tonkinensis (Euphorbiaceae), together with five known aryltetralin lignans, cleisindoside B (8), cleistantoxin (9), cleisindoside D (10), neocleistantoxin (11) and polygamain (12). Their structures were established from spectral analysis, including mass spectrometry and 2D-NMR. The absolute configurations of 4-7 were determined by analysis of their experimental CD spectra and comparison with calculated electronic circular dichroism (ECD) spectra. Compounds 2 and 6 had selective inhibition with moderate cytotoxicity against Pan C1 and A549 cell lines, respectively. Cleistantoxin (9) was significantly active against A549, HeLa, Hep3B, Pan C1 and MCF7 cell lines while it was less cytotoxic against HeLa cells. Neocleistantoxin (11) exhibited remarkable inhibition toward A549, HeLa, MCF7 and Pan C1. This is the first report for cytotoxicity of 9 and 11 against A549, Hep3B and Pan C1 cell lines.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Nguyen LH,Vu VN,Phi Thi D,Tran VH,Litaudon M,Roussi F,Nguyen VH,Chau VM,Doan Thi Mai H,Pham VCdoi
10.1016/j.fitote.2019.104432subject
Has Abstractpub_date
2020-01-01 00:00:00pages
104432eissn
0367-326Xissn
1873-6971pii
S0367-326X(19)32027-1journal_volume
140pub_type
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