Abstract:
:Three new clerodane type diterpenoids (2-4), together with one known analogues (1), were isolated from the tuberous roots of Tinospora sagittata (Oliv.) Gagnep. Compound 3 is an unusual clerodane diterpenoid with the carbonyl functionality at C-3, which represents the first example from this diterpenoid compounds class. The structures were established on the basis of spectroscopic data interpretation. The absolute configuration of 1 was determined for the first time by single-crystal X-ray diffraction analysis with CuKα irradiation. These isolates were evaluated for their cytotoxic activities against five human cancer cell lines and inhibitory activities on LPS-induced NO production in RAW264.7 cells.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Zhang G,Ma H,Hu S,Xu H,Yang B,Yang Q,Xue Y,Cheng L,Jiang J,Zhang J,Wang F,Zhang Ydoi
10.1016/j.fitote.2016.02.012subject
Has Abstractpub_date
2016-04-01 00:00:00pages
59-65eissn
0367-326Xissn
1873-6971pii
S0367-326X(16)30041-7journal_volume
110pub_type
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