Abstract:
:Diterpene alkaloids neoline (1), napelline (2), isotalatizidine (3), karakoline (4), senbusine A (5), senbusine C (6), aconitine (7) and taurenine (8) were identified from Aconitum napellus L. subsp. firmum, four (2-4, 6) of which are reported for the first time from this plant. The structures were determined by means of LC-MS, 1D and 2D NMR spectroscopy, including (1)H-(1)H COSY, NOESY, HSQC and HMBC experiments. Electrophysiological effects of the isolated compounds, together with nine diterpene alkaloids previously obtained from Aconitum toxicum and Consolida orientalis were investigated on stable transfected HEK-hERG (Kv11.1) and HEK-GIRK1/4 (Kir3.1 and Kir3.4) cell lines using automated patch clamp equipment. Significant blocking activity on GIRK channel was exerted by aconitine (7) (45% at 10 μM), but no blocking activities of the other investigated compounds were detected. The tested compounds were inactive on hERG channel in the tested concentration. The comparison of the previously reported metabolites of A. napellus subsp. firmum and compounds identified in our experiment reveals substantial variability of the alkaloid profile of this taxon.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Kiss T,Orvos P,Bánsághi S,Forgo P,Jedlinszki N,Tálosi L,Hohmann J,Csupor Ddoi
10.1016/j.fitote.2013.07.010subject
Has Abstractpub_date
2013-10-01 00:00:00pages
85-93eissn
0367-326Xissn
1873-6971pii
S0367-326X(13)00181-0journal_volume
90pub_type
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