当前位置： SCI文献检索 > FITOTERAPIA期刊下所有文献 > Five novel naphthylisoquinoline alkaloids with growth inhibitory activities against human leukemia cells HL-60, K562 and U937 from stems and leaves of Ancistrocladus tectorius.

Five novel naphthylisoquinoline alkaloids with growth inhibitory activities against human leukemia cells HL-60, K562 and U937 from stems and leaves of Ancistrocladus tectorius.

Abstract：

:Two new 7,6'-coupled naphthylisoquinolines, namely ancistrotectorines A (1) and B (2), two new 5,3'-coupled naphthylisoquinolines, namely ancistrotectorines C (3) and D (4), and one new 7,8-coupled naphthylisoquinoline, namely ancistrotectorine E (5), together with 9 known naphthylisoquinoline alkaloids, hamatine (6), ancistrobertsonine B (7), ancistrocladinine (8), hamatinine (9), ancistrotanzanine A (10), ancistrotanzanine B (11), ancistrotectoriline B (12), 7-epi-ancistrobrevine D (13), and ancistrotectorine (14), were isolated from the 70% EtOH extract of Ancistrocladus tectorius. Their structures were elucidated based on the extensive analysis of spectroscopic data (1D, 2D NMR and MS). Compound 5 exhibited inhibitory activities against HL-60, K562 and U937 cell lines with IC50 values of 1.70, 4.18 and 2.56 μM respectively.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Jiang C,Li ZL,Gong P,Kang SL,Liu MS,Pei YH,Jing YK,Hua HM

doi

10.1016/j.fitote.2013.09.010

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

305-312

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(13)00245-1

journal_volume

91

pub_type

杂志文章

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