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Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells.

Abstract：

:StAPs are potato aspartic proteases with cytotoxic activity against plant pathogens and spermatozoa. StAPs cytotoxic activity is selective, since these proteins do not exert toxic effect on plant cells and erythrocytes. In this work, we investigated the capacity of StAPs to exert cytotoxicity on human leukaemia cells. Obtained results show that StAPs induce apoptosis on Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no significative effect on the T lymphocytes viability was observed at all StAPs incubation times and concentrations tested. These results suggest that StAPs can be conceptually promising leads for cancer therapy.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Mendieta JR,Fimognari C,Daleo GR,Hrelia P,Guevara MG

doi

10.1016/j.fitote.2009.10.004

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

329-35

issue

5

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(09)00249-4

journal_volume

81

pub_type

杂志文章

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