Abstract：
:Three new phloroglucinols, baeckenones D-F (1-3), were obtained from the leaves of Indonesian Baeckea frutescens, along with the known unusual endoperoxide, phloroglucinol (4). The structures of the isolated compounds were elucidated by 1D and 2D NMR and HREIMS spectra. Furthermore, the stereochemistry of baeckenone D (1) was established by an X-ray diffraction analysis. Among the isolated compounds 1-4, baeckenone F (3) showed moderate cytotoxic activities against human pancreatic (PSN-1), lung (A549), and breast (MDA-MB-231) cancer cell lines, with IC50 values of 33.3 μM, 34 μM, and 39.3 μM, respectively.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Nisa K,Ito T,Kodama T,Tanaka M,Okamoto Y,Asakawa Y,Imagawa H,Morita Hdoi
10.1016/j.fitote.2016.01.013subject
Has Abstractpub_date
2016-03-01 00:00:00pages
236-40eissn
0367-326Xissn
1873-6971pii
S0367-326X(16)30015-6journal_volume
109pub_type
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