Abstract:
:Three new furoquinoline alkaloids, leptanoines A-C (1-3) along with three known compounds (4-6) were isolated from the leaves of Evodia lepta. Their structures were identified by interpretation of their spectroscopic data as well as comparison with those reported in the literature. In addition, all isolated compounds were evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. Compound 4 showed the highest inhibitory activity towards BChE with an IC50 value of 47.9 μM. On the other hand, Compound 5 showed the highest inhibitory activity towards AChE with an IC50 value of 69.1 μM.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Sichaem J,Jirasirichote A,Sapasuntikul K,Khumkratok S,Sawasdee P,Do TM,Tip-pyang Sdoi
10.1016/j.fitote.2013.12.002subject
Has Abstractpub_date
2014-01-01 00:00:00pages
270-3eissn
0367-326Xissn
1873-6971pii
S0367-326X(13)00311-0journal_volume
92pub_type
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