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Caffeoylserotonin suppresses THP-1 monocyte adhesion and migration via inhibition of the integrin β1/FAK/Akt signalling pathway.

Abstract：

:We investigated the effect of caffeoylserotonin (CaS) on THP-1 monocyte migration and adhesion to fibronectin in response to MCP-1. CaS decreased monocyte adhesion and migration induced by MCP-1, together with CCR2 expression and α5β1 integrin, and activated β1 integrin expression on the cell surface. CaS also inhibited FAK and Akt phosphorylation. We found that CaS had anti-inflammatory activity based on inhibition of adhesion and migration via inhibition of the integrin β1/FAK/Akt signalling pathway. Thus, the inhibitory effects of CaS on monocyte function may support the future development of this compound as a potential treatment for inflammation-dependent diseases.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Yoon JH,Kim HE,Choi JY,Bae HJ,Lee SG

doi

10.1016/j.fitote.2012.04.025

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

1364-70

issue

8

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(12)00132-3

journal_volume

83

pub_type

杂志文章

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