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Anticholinesterase activity of standardized extract of Illicium verum Hook. f. fruits.

Abstract：

:Illicium verum is a well known spice in traditional Indian system for its therapeutic potential. The present study was aimed to evaluate the acetylcholinesterase (AChE) and butyrylcholinesterase inhibitory (BChE) activity of standardized extracts of I. verum and its oil. Present study confirmed that anethole contributed to the anticholinesterase activity of I. verum, with more specificity towards AChE. IC(50) for AChE and BChE inhibitory activity of anethole was 39.89±0.32 μg/mL and 75.35±1.47 μg/mL, whereas for the oil, 36.00±0.44 μg/mL and 70.65±0.96 μg/mL respectively. Therefore I. verum can be a good lead as anti-cholinesterase agent from natural resources.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Bhadra S,Mukherjee PK,Kumar NS,Bandyopadhyay A

doi

10.1016/j.fitote.2010.11.003

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

342-6

issue

3

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(10)00283-2

journal_volume

82

pub_type

杂志文章

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