Abstract：
:Rubus ideaus L., a member of the Rosaceae family, is popular for its distinctive flavor and attractive red color. In order to explore the functional factors possibly presented in the fruit, seven new benzofuran neolignans (1a/1b-3a/3b and 4b), together with one known neolignan 4a, were isolated from the fruit of R. ideaus. Compounds 1a/1b-4a/4b as four pairs of enantiomers were separated on a chiral chromatographic column. Their structures including absolute configurations were elucidated by extensive spectroscopic data analyses, including UV, IR, HRESIMS, NMR, and comparing their experimental electronic circular dichroism (ECD) spectra with calculated ECD spectra. Additionally, all these enantiomeric compounds were evaluated for their antioxidant, neuroprotective, and anti-Aβ1-42 aggregation activities.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Zhou L,Xi YF,Wang W,Lin B,Wang XB,Huang XX,Song SJdoi
10.1016/j.fitote.2018.01.012subject
Has Abstractpub_date
2018-06-01 00:00:00pages
56-61eissn
0367-326Xissn
1873-6971pii
S0367-326X(17)31860-9journal_volume
127pub_type
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