Abstract:
:Four new sesquiterpenes (1-2, 6-7), a new pyranone glycoside (10) along with six known compounds, were isolated from the whole plant of Erigeron breviscapus. Their planar structures were elucidated using extensive spectroscopic analyses. Brevisterpene A (1) and brevisterpene B (2) were proved to be a pair of diastereomer followed by mixtures resolution using chiral HPLC. Their absolute configurations were determined by ECD calculation. The relative configuration of brevisnoside B (7) was elucidated by a combined analysis of NOESY spectrum and computation of 13C NMR chemical shifts, and determination of the absolute configurations of 6 and 7 assisted by optical rotation calculations. Compounds 1 and 2 displayed moderate neuroprotective effects against H2O2-induced damage in SH-SY5Y cells.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Han S,Liu Y,Hou Z,Sun X,Yao G,Gao P,Li L,Song Sdoi
10.1016/j.fitote.2019.104288subject
Has Abstractpub_date
2019-10-01 00:00:00pages
104288eissn
0367-326Xissn
1873-6971pii
S0367-326X(19)31424-8journal_volume
138pub_type
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