Abstract：
:Two new natural products, 5-O-[β-D-apiofuranosyl-(1→6)-β-d-glucopyranosyl]-1-isoindolinone (1) as well as N-(2E)-3-[(2S,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]acryloylglycine (2), along with four known compounds (3-6), were isolated from the methanolic extract of Cordia alliodora root bark. Furthermore, the methanolic extract of Cordia colloccoca leaves, afforded the known flavonoids afzelin (7) and quercitrin (8). The isolated secondary metabolites were assayed for their antimicrobial activities against a panel of 6g positive and negative bacteria and three human pathogenic fungi. Moreover, their antiproliferative effect was also evaluated in vitro against the human non-small-cell bronchopulmonary carcinoma line NSCLC-N6, the epidermoid lung cancer cell line A549 as well as the normal human skin fibroblast cell line (AG01523).
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Fouseki MM,Damianakos H,Karikas GA,Roussakis C,P Gupta M,Chinou Idoi
10.1016/j.fitote.2016.09.004subject
Has Abstractpub_date
2016-12-01 00:00:00pages
9-14eissn
0367-326Xissn
1873-6971pii
S0367-326X(16)30378-1journal_volume
115pub_type
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