Metabolism mediated interaction of α-asarone and Acorus calamus with CYP3A4 and CYP2D6.

abstract：:Aconitum carmichaelii has been used in traditional Chinese medicine for treating various diseases for several thousand years. Based on the biosynthetic pathway of some alkaloids such as C19-diterpenoid alkaloids and obvious differences in alkaloid content between leaves of two A. carmichaelii varieties has been report...

journal_title：Fitoterapia

authors： Yang Y,Hu P,Zhou X,Wu P,Si X,Lu B,Zhu Y,Xia Y

更新日期：2020-01-01 00:00:00

abstract：:Glutamate-induced excitotoxicity is a key pathological mechanism in many neurological disease states. Ecdysterones derived from Rhaponticum carthamoides (Willd.) Iljin (RCI) have been shown to alleviate glutamate-induced neuronal damage; although their mechanism of action is unclear, some data suggest that they enhanc...

journal_title：Fitoterapia

authors： Wu J,Gao L,Shang L,Wang G,Wei N,Chu T,Chen S,Zhang Y,Huang J,Wang J,Lin R

更新日期：2017-06-01 00:00:00

abstract：:Two new ent-kaurene diterpenoids, 15α-acetoxyl-6,11α-epoxy-6α-hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7-olide (1), 15α-hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (2), together with ten known compounds (5-14) were isolated from the leaves of Isodon rubescens. Their structures were elucidated mainly by ...

journal_title：Fitoterapia

authors： Xie RJ,Yan FL,Hai GF,Hou RJ,Ding MM,Bai YX

更新日期：2011-06-01 00:00:00

abstract：:The cardioprotective effect of Prunella vulgaris ethylacetate fraction (PVEF) and its constituent rosmarinic acid (RA) was evaluated on isolated rat cardiomyocytes subjected to doxorubicin-induced oxidative stress. The cytoprotectivities of PVEF and RA were concentration-dependent in the range of 0.005 to 0.05 mg/ml a...

journal_title：Fitoterapia

authors： Psotová J,Chlopcíková S,Miketová P,Simánek V

更新日期：2005-09-01 00:00:00

abstract：:Three new furoquinoline alkaloids, leptanoines A-C (1-3) along with three known compounds (4-6) were isolated from the leaves of Evodia lepta. Their structures were identified by interpretation of their spectroscopic data as well as comparison with those reported in the literature. In addition, all isolated compounds ...

journal_title：Fitoterapia

authors： Sichaem J,Jirasirichote A,Sapasuntikul K,Khumkratok S,Sawasdee P,Do TM,Tip-pyang S

更新日期：2014-01-01 00:00:00

abstract：:Infusions of Picrolemma sprucei roots, stems and leaves are used in traditional medicine throughout the Amazon region from the Guianas to Brazil and Peru in the treatment of gastritis, intestinal helminths and malaria. As there are no studies describing its mode of action in providing a gastroprotective effect, we det...

journal_title：Fitoterapia

authors： Vieira SM,Silva RL,Lemos HP,Amorim RC,Silva EC,Reinach PS,Cunha FQ,Pohlit AM,Cunha TM

更新日期：2014-06-01 00:00:00

abstract：:Antioxidant activity of the ethanol extract of Erigeron breviscapus (EEEB) were studied by using neuron oxidative injury model induced by superoxide radical. EEEB at the dose of 10-140 mug/ml reduced significantly the lipid peroxidation levels and lactic dehydrogenase (LDH) release from neuron exposed to superoxide ra...

journal_title：Fitoterapia

authors： Liu H,Yang X,Ren T,Feng Y,Xu H

更新日期：2005-12-01 00:00:00

abstract：:Investigators and sponsors of dietary supplement research need to know the relevant regulatory requirements and how to comply with them. This brief review describes how research on dietary supplements is regulated by FDA. In general, whether an FDA sanctioned Investigational New Drug (IND) application is required for ...

journal_title：Fitoterapia

authors： Chen ST

更新日期：2011-01-01 00:00:00

abstract：:Four meroterpenoids, applanatumols F (1), H (3), I (2), and lingzhiol (4) were isolated from the 95% EtOH extract of the fruiting bodies of Ganoderma sinense. Their structures were established on the basis of NMR spectroscopic analyses, optical rotatory dispersion data, ECD spectra, and X-ray crystallography. Compound...

journal_title：Fitoterapia

authors： Gao S,Zhang P,Zhang C,Bao F,Li H,Chen L

更新日期：2018-11-01 00:00:00

abstract：:Chemical examination of the ethanol extract of rhizomes of Iris tectorum led to the isolation and characterization of three new lignans, (7R,7'R,8S,8'S)-5'-methoxy-neo-olivil (1a), (7S,7'S,8R,8'R) -5'-methoxy-neo-olivil (1b), (7S,7'R,8S,8'S)-neo-olivil (2a), (7R,7'S,8R,8'R)-neo-olivil (2b), (7R,7'R,8S,8'S,7''S,8''S)-t...

journal_title：Fitoterapia

authors： Zhang CL,Wang Y,Liu YF,Liang D,Hao ZY,Luo H,Chen RY,Yu DQ

更新日期：2016-01-01 00:00:00

abstract：:Total sennosides concentration is a very important factor when rhubarb and senna will be used as crude drugs. However, one-step analytical technique for total sennosides has not been reported except HPLC. An enzyme-linked immunosorbent assay (ELISA) for total sennosides concentration by using the combination of anti-s...

journal_title：Fitoterapia

authors： Morinaga O,Uto T,Sakamoto S,Tanaka H,Shoyama Y

更新日期：2009-01-01 00:00:00

abstract：:Rats treated with 100 mg /kg/day of the Catharanthus roseus ethanol extract had high rate of wound contraction significantly decreased epithelization period, significant increase in dry weight and hydroxyproline content of the granulation tissue when compared with the controls. Wound contraction together with increase...

journal_title：Fitoterapia

authors： Nayak BS,Anderson M,Pinto Pereira LM

更新日期：2007-12-01 00:00:00

abstract：:Isothiocyanates (ITCs), the breakdown products of glucosinolates found primarily in species of Brassicaceae (Cruciferae), are potential anti-cancer compounds. This review compiles data on how through different modes of action ITCs and their synthetic counterparts target leukemia. ...

journal_title：Fitoterapia

authors： Prashar A,Siddiqui F,Singh AK

更新日期：2012-03-01 00:00:00

abstract：:The genus Cyclopia (Fabaceae family) includes a number of shrubs endemic to Cape Fynbos region of South Africa. The most common of these plants is Cyclopia intermedia E. Mey., used together with other Cyclopia species (mainly C. subternata and C. sessiliflora) to manufacture the honeybush herbal tea which has been pro...

journal_title：Fitoterapia

authors： Kokotkiewicz A,Luczkiewicz M

更新日期：2009-01-01 00:00:00

abstract：:Seven oleanane-type triterpenoid saponins, tunicosaponins B-D (1-3), F-I (4-7), along with eight known triterpenoid saponins (8-15), were isolated from the roots of Psammosilene tunicoides. The structures of compounds 1-7 were determined by comprehensive spectroscopic analysis, including 1D and 2D NMR techniques, mass...

journal_title：Fitoterapia

authors： Wen B,Tian JM,Huang ZR,Xiao SJ,Yuan WL,Wang JX,Li HL,Xu XK,Shen YH

更新日期：2020-07-01 00:00:00

abstract：:The present study investigated the effects of isopulegol, a monoterpene alcohol, in PTZ-induced convulsions and verified possible involved mechanisms. Saline, isopulegol or diazepam were intraperitonealy injected 30 min before PTZ. The latency for development of convulsions and mortality, as well as the mortality prot...

journal_title：Fitoterapia

authors： Silva MI,Silva MA,de Aquino Neto MR,Moura BA,de Sousa HL,de Lavor EP,de Vasconcelos PF,Macêdo DS,de Sousa DP,Vasconcelos SM,de Sousa FC

更新日期：2009-12-01 00:00:00

abstract：:With the goal of unravelling antimicrobial agents and mixtures inspired by plant defences, we investigated the antibacterial and antifungal efficacy of Hirtellina lobelii DC. essential oil (EO), both alone and in combination with antimicrobial drugs. Hirtellina lobelii DC. EO was analysed by GC, GC-MS and partial frac...

journal_title：Fitoterapia

authors： Khoury M,El Beyrouthy M,Ouaini N,Eparvier V,Stien D

更新日期：2019-03-01 00:00:00

abstract：:Tithonia diversifolia (Asteraceae), is used as traditional medicine in tropical countries for the treatment of various diseases, including malaria. Although numerous studies have assessed the antimalarial properties, nothing is known about the effect of T. diversifolia extracts on trypanosomiasis. In this study extrac...

journal_title：Fitoterapia

authors： Sut S,Dall'Acqua S,Baldan V,Ngahang Kamte SL,Ranjbarian F,Biapa Nya PC,Vittori S,Benelli G,Maggi F,Cappellacci L,Hofer A,Petrelli R

更新日期：2018-01-01 00:00:00

abstract：:Salvianolic acid B (Sal B) is the most abundant phenolic compound in Salvia miltiorrhiza, which has been widely used for the treatment of cardiovascular diseases in Oriental medicine. To elucidate structure of the converted compounds of Sal B by decoction in aqueous solution, Sal B (200 mg) was decocted in an aqueous ...

journal_title：Fitoterapia

authors： Lee HJ,Cho JY,Moon JH

更新日期：2012-10-01 00:00:00

abstract：:A new monodesmosidic spirostanol saponin, along with three known saponins was isolated from Agave macroacantha Zucc leaves. The structure of the new saponin was established as hecogenin-3-O-alpha-L-rhamnopyranosyl (1-->4) beta-D-xylopyranosyl (1-->3)[beta-D-glucopyranosyl (1-->2)] beta-D-glucopyranosyl (1-->4) beta-D-...

journal_title：Fitoterapia

authors： Eskander J,Lavaud C,Harakat D

更新日期：2010-07-01 00:00:00

abstract：:Wedelia (Sphagneticola trilobata, Syn. Wedelia trilobata), a notoriously invasive agricultural weed, can inhibit the growth and development of crops in the field. Eight new eudesmanolides (1-8), along with twelve known congeners (9-20), were isolated and identified from the flowers of Wedelia. Their chemical structure...

journal_title：Fitoterapia

authors： Sun L,Wang Z,Wang Y,Xu J,He X

更新日期：2020-04-01 00:00:00

abstract：:Five new megastigmane glycosides, urenalobasides A-E (1-5), together with 11 known ones (6-16) were isolated from Urena lobata. Their structures were determined by extensive spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism method. Compounds 1 and 2 are ...

journal_title：Fitoterapia

authors： Su C,Qi B,Wang J,Ding N,Wu Y,Shi XP,Zhu ZX,Liu X,Wang XH,Zheng J,Tu PF,Shi SP

更新日期：2018-06-01 00:00:00

abstract：:A total of 58 fungal isolates, belonging to 24 genera, were obtained from the leaves, stems and roots of Ginkgo biloba L.. Among them, one endophytic fungal strain, Penicillium cataractum SYPF 7131, displayed the strongest antibacterial activity. Four new compounds (1-4) were isolated from the strain fermentation brot...

journal_title：Fitoterapia

authors： Wu YY,Zhang TY,Zhang MY,Cheng J,Zhang YX

更新日期：2018-07-01 00:00:00

abstract：:Caesalpinone A (1), a new type of gorgonane sesquiterpenoid containing an unprecedented 1,15-bridge, along with ten known sesquiterpenoids (2-11) were isolated from the pods of Caesalpinia spinosa Kuntze (Tara). The structure of caesalpinone A was elucidated based on its 1D and 2D NMR spectra. The absolute configurati...

journal_title：Fitoterapia

authors： Mu W,Tang H,Li Y,He D,Ma R,Wang L

更新日期：2016-07-01 00:00:00

abstract：:The tea seed triterpene saponin (TS) from Camellia sinensis was found to exhibit better antitumor activity in vivo in S180 implanted ICR mice and QR inducing activity for hepa lclc7 cells respectively compared with the total tea seed saponin (TTS), hydrolysate of the TTS and tea seed flavonoid glycosides (TF). By bioa...

journal_title：Fitoterapia

authors： Li N,Ma ZJ,Chu Y,Wang Y,Li X

更新日期：2013-01-01 00:00:00

abstract：:The ethanolic extracts of Lawsonia inermis leaves, Holarrhena antidysenterica bark, Swertia chirata whole plant and Mangifera indica bark were tested (in-vitro) for alpha-glucosidase inhibitory activity. M. indica extract was found to be the most potent, with an IC(50) value of 314 microg/ml. ...

journal_title：Fitoterapia

authors： Prashanth D,Amit A,Samiulla DS,Asha MK,Padmaja R

更新日期：2001-08-01 00:00:00

abstract：:Five rare dichloro aromatic polyketides (1-5) were obtained from an endophytic fungus Penicillium sp., along with five known metabolites (6-10). Their structures were elucidated by extensive spectroscopic analysis, Mosher methods, as well as [Rh2(OCOCF3)4]-induced electronic circular dichroism (ECD) experiments. Compo...

journal_title：Fitoterapia

authors： Yang MH,Li TX,Wang Y,Liu RH,Luo J,Kong LY

更新日期：2017-01-01 00:00:00

abstract：:1,2-Dihydroxyanthraquinone (1) was isolated from the seed of Cassia obtusifolia through bioassay-guided fractionation. 1,2-Dihydroxyanthraquinone strongly inhibited the growth of Clostridium perfringens and Escherichia coli. Structure-activity relationship revealed that 1,4-dihydroxyanthraquinone (2) and 1,8-dihydroxy...

journal_title：Fitoterapia

authors： Sung BK,Kim MK,Lee WH,Lee DH,Lee HS

更新日期：2004-07-01 00:00:00

abstract：:Thuja occidentalis L. is indigenous for Northern America and commonly cultivated in Europe. Raw materials obtained from this tree are widely applied in the ethnomedicine and phytotherapy of numerous ailments, incl. scurvy, cystitis, rheumatism and cancer. Despite wide medicinal applications of Thuja occidentalis, stil...

journal_title：Fitoterapia

authors： Pudełek M,Catapano J,Kochanowski P,Mrowiec K,Janik-Olchawa N,Czyż J,Ryszawy D

更新日期：2019-04-01 00:00:00

abstract：:Nagilactones are norditerpene dilactones isolated from the root bark of Podocarpus nagi. Although nagilactone E has been reported to show antifungal activities, its activity is weaker than that of antifungals on the market. Nagilactone E enhances the antifungal activity of phenylpropanoids such as anethole and isosafr...

journal_title：Fitoterapia

authors： Hayashi K,Yamaguchi Y,Ogita A,Tanaka T,Kubo I,Fujita KI

更新日期：2018-07-01 00:00:00