Abstract:
:Three new xanthones, oblongixanthone F-H (1-3), along with eight known xanthones (4-11), were isolated from an EtOAc extract of the twigs of Garcinia oblongifolia. Their structures were elucidated by spectroscopic analysis including 1D- and 2D-NMR spectroscopy and mass spectrometry. The antidiabetic effects of all isolated compounds were evaluated by in vitro α-glucosidase and PTP1B inhibition assays. Compound 11 was the most active compound, and inhibited α-glucosidase and PTP1B with IC50 values of 1.7±0.5 and 14.1±3.5μM, respectively.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Trinh BT,Quach TT,Bui DN,Staerk D,Nguyen LD,Jäger AKdoi
10.1016/j.fitote.2017.03.003subject
Has Abstractpub_date
2017-04-01 00:00:00pages
126-131eissn
0367-326Xissn
1873-6971pii
S0367-326X(17)30185-5journal_volume
118pub_type
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