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Analgesic, anti-inflammatory, and CNS depressant activities of new constituents of Nepeta clarkei.

Abstract：

:Two new pentacyclic triterpenes named kirmanoic acid (1) and kurramanoic acid (2) have been isolated from the chloroform-soluble portion of the whole plant of Nepeta clarkei Hook. The structures of the two new compounds were assigned on the basis of their ¹H and ¹³C NMR spectra including two-dimensional NMR techniques such as COSY, HMQC, and HMBC experiments. Kirmanoic acid (1) was investigated for analgesic, anti-inflammatory, and CNS depressant activities. Interestingly kirmanoic acid (1) showed strong analgesic activity than standard drug in acetic induced writhing and formalin tests. Similarly kirmanoic acid (1) also showed strong anti-inflammatory activity than its standard drug. The gross behavioral study of kirmanoic acid (1) revealed that it exhibited mild CNS stimulant and muscle relaxant in the mice. Compound 1 showed a slight increase in Locomotor activity and possesses the antidepressant effect.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Hussain J,Ur Rehman N,Hussain H,Al-Harrasi A,Ali L,Rizvi TS,Ahmad M,Mehjabeen

doi

10.1016/j.fitote.2012.01.002

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

593-8

issue

3

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(12)00028-7

journal_volume

83

pub_type

杂志文章

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