Abstract:
:Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20β-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirmed by X-ray crystal diffraction. Primary bioassays showed that compound 1 had significant cytotoxic activity against Hela, PC3 and HepG2 cells, with IC(50) of 2.92 μM, 1.08 μM and 2.45 μM, respectively.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Liang YH,Wang W,Yu SW,Ye M,He XH,Gong NB,Lu Y,Khan IA,Guo DAdoi
10.1016/j.fitote.2010.06.013subject
Has Abstractpub_date
2010-12-01 00:00:00pages
988-91issue
8eissn
0367-326Xissn
1873-6971pii
S0367-326X(10)00143-7journal_volume
81pub_type
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