A new chiratane type triterpenoid from the rhizomes of Drynaria fortunei.

Abstract:

:Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20β-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirmed by X-ray crystal diffraction. Primary bioassays showed that compound 1 had significant cytotoxic activity against Hela, PC3 and HepG2 cells, with IC(50) of 2.92 μM, 1.08 μM and 2.45 μM, respectively.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Liang YH,Wang W,Yu SW,Ye M,He XH,Gong NB,Lu Y,Khan IA,Guo DA

doi

10.1016/j.fitote.2010.06.013

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

988-91

issue

8

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(10)00143-7

journal_volume

81

pub_type

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