Abstract:
:The present study investigated the effects of isopulegol, a monoterpene alcohol, in PTZ-induced convulsions and verified possible involved mechanisms. Saline, isopulegol or diazepam were intraperitonealy injected 30 min before PTZ. The latency for development of convulsions and mortality, as well as the mortality protection percentage was recorded. For investigating the involvement of GABAergic system, flumazenil was utilized. The activity of antioxidant enzyme catalase as well as the levels of reduced glutathione and lipid peroxidation were measured in brain hippocampus. Similarly to diazepam, isopulegol significantly prolonged the latency for convulsions and mortality of mice. All animals were protected against mortality at higher dose of isopulegol. Flumazenil pretreatment decreased the prolongation of seizure latency induced by both diazepam and isopulegol, although it was not able to reverse the latency and protection percent for mortality. Isopulegol also significantly prevented PTZ-induced increase in lipid peroxidation, preserved catalase activity in normal levels, and prevented the PTZ-induced loss of GSH in hippocampus of mice. These results suggest that the anticonvulsant and bioprotective effects of isopulegol against PTZ-induced convulsions are possibly related to positive modulation of benzodiazepine-sensitive GABA(A) receptors and to antioxidant properties.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Silva MI,Silva MA,de Aquino Neto MR,Moura BA,de Sousa HL,de Lavor EP,de Vasconcelos PF,Macêdo DS,de Sousa DP,Vasconcelos SM,de Sousa FCdoi
10.1016/j.fitote.2009.06.011subject
Has Abstractpub_date
2009-12-01 00:00:00pages
506-13issue
8eissn
0367-326Xissn
1873-6971pii
S0367-326X(09)00141-5journal_volume
80pub_type
杂志文章相关文献
FITOTERAPIA文献大全abstract::Investigation of the bioactive secondary metabolites of the marine actinomycetes Rubrobacter radiotolerans led to the isolation and characterization of two naturally rare dimeric indole derivatives (1 and 2). The structures of these new compounds were elucidated by spectroscopic data interpretation, and the absolute c...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2015.01.014
更新日期:2015-04-01 00:00:00
abstract::The antifungal activity of fresh, aqueous Brassica oleracea var. botrytis juice against Candida albicans and other pathogenic fungi was investigated. The juice was found to be effective both in inhibiting the growth of blastoconidia and reducing the appearance of C. albicans germ tubes. Furthermore, the juice inhibite...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(03)00108-4
更新日期:2003-07-01 00:00:00
abstract::8,2'-Diprenylquercetin 3-methyl ether, a natural product with prominent anti-breast cancer activity, is the main active constituent of Sinopodophylli Fructus. A high-performance liquid chromatography with a diode array detector coupled with electrospray ionization ion trap time-of-flight multistage mass spectrometry (...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2019.104191
更新日期:2019-09-01 00:00:00
abstract::Ten coumarins were isolated from Peucedanum luxurians. The rare coumarins stenocarpin, stenocarpin isobutyrate, officinalin, officinalin isobutyrate, 8-methoxypeucedanin and the known xanthotoxin, isoimperatorin, bergaptene, peucedanin and cnidilin were isolated. All isolated compound were identified by means of spect...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2007.04.004
更新日期:2007-09-01 00:00:00
abstract::Two new naphthofuranone derivatives, 11-hydroxy-2-O-methylhibiscolactone A (1) and O-methylhibiscone D (2), have been isolated from the stems of Pachira aquatica, together with 18 known compounds (3-20). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compo...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2016.12.008
更新日期:2017-03-01 00:00:00
abstract::The purpose of this study was to determine the photoprotective properties of the methanolic extract of Buddleja scordioides, as well as verbascoside and linarin which were isolated from this extract, and linarin acetate prepared in the laboratory. The photoprotective effect of substances against UV-B induced cellular ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2005.03.009
更新日期:2005-06-01 00:00:00
abstract::Ganoderma cochlear, as edible and medicinal fungus, has long been used to prevent and treat various diseases. As our continuously phytochemical investigation of this fungus, a HPLC-UV-guided method led to the isolation of nine previously undescribed aromatic meroterpenoids with different ring systems, including six pa...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2018.03.005
更新日期:2018-06-01 00:00:00
abstract::Two new triterpenoid estersaponins (1, 2) were isolated from the leaves of Pittosporum tobira 'Variegata' (Thunb.) W. T. Aiton, along with one known saponin (3) and one known flavonoid glycoside (4). Their structures were established by different spectroscopic methods including 1D and 2D NMR, UV, as well as ESI-MS ana...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2015.09.006
更新日期:2015-10-01 00:00:00
abstract::Calcium-activated chloride channels (CaCCs) as a kind of widely expressed ion channels play crucial roles in a variety of physiological regulation. TMEM16A has been identified as the molecular basis of CaCCs in numerous cell types and is considered a new drug target for many diseases. Regulating the function of TMEM16...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2020.104736
更新日期:2020-11-01 00:00:00
abstract::Three new xanthones, cylindroxanthones A-C (1-3), were isolated from the stem bark of Garcinia cylindrocarpa. The structures were established on the basis of spectroscopic analysis. The molecular structure of 1 was unequivocally confirmed by single-crystal X-ray diffraction analysis. These three xanthones were evaluat...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2015.11.017
更新日期:2016-01-01 00:00:00
abstract::Escin exerts potent glucocorticoid-like anti-inflammatory effects. The aim of this study was to investigate whether the anti-inflammatory effect of escin is through the up-regulation of glucocorticoids and if escin induces pathological changes in immune organs. Mice were administrated with escin intravenously for 7 da...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2011.04.004
更新日期:2011-09-01 00:00:00
abstract::A new flavone, 4'-hydroxy-6,7-methylenedioxy-3-methoxyflavone 1, and two other nucleosides, ribavirin 2 and adenosine 3, were isolated from the leaves of Dulacia egleri. The nucleosides were identified by spectroscopic techniques (1D, 2D-NMR) while the structure of the flavonoid was established by 1D, 2D-NMR analysis,...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2018.08.005
更新日期:2019-01-01 00:00:00
abstract::StAPs are potato aspartic proteases with cytotoxic activity against plant pathogens and spermatozoa. StAPs cytotoxic activity is selective, since these proteins do not exert toxic effect on plant cells and erythrocytes. In this work, we investigated the capacity of StAPs to exert cytotoxicity on human leukaemia cells....
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2009.10.004
更新日期:2010-07-01 00:00:00
abstract::Five new 2-(2-phenylethyl)chromone derivatives (1-5), along with eleven known compounds (6-16) were isolated from Chinese agarwood. Their structures were elucidated by spectroscopic data (NMR, UV, IR, and MS) analyses and comparison of their spectroscopic and physical data with the literature values. The absolute conf...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2017.02.009
更新日期:2017-04-01 00:00:00
abstract::Cranberry procyanidins and quercetin derivatives are considered possible active compounds against urinary tract infections (UTIs). In this paper a small group (n=6) of healthy subjects consumed a product containing 360mg of cranberry extract (42.6% w/w of PAC-A and 14.6% w/w of PAC-B) and 200mg of quercetin. Urine sam...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2017.08.014
更新日期:2017-10-01 00:00:00
abstract::The antioxidant activity of Agrimonia eupatoria (Agrimony) and Agrimonia procera (Fragrant agrimony) extracts was assessed by measuring in DPPH radical scavenging and ABTS(+) radical decolourisation reaction systems. Radical scavenging capacity of agrimony extracts varied in a wide range (9.1-97.5% in DPPH reaction an...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2006.10.002
更新日期:2007-02-01 00:00:00
abstract::Chemical investigation of the liquid culture of the endophytic fungus Bipolaris sorokiniana A606, which was isolated from the medicinal plant Pogostemon cablin resulted in the isolation of four new cytotoxic compounds, named isocochlioquinones D-E (1-2) and cochlioquinones G-H (3-4), along with five known cochlioquino...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2016.02.005
更新日期:2016-04-01 00:00:00
abstract::The crude extracts of the leaves of Dodonaea viscosa and Rumex nervosus as well as of the root of Rumex abyssinicus were tested for anti-microbial and anti-inflammatory activities. It was observed that the three plants possess antibacterial activity against Streptococcus pyogenes and Staphylococcus aureus and strong a...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(02)00315-5
更新日期:2003-02-01 00:00:00
abstract::Two new guaiane-type sesquiterpenoids containing an interesting epoxy unit, daucuside (1) and daucusol (2) were isolated from the fruits of Daucus carota L. Their chemical structures were elucidated on the basis of MS, NMR spectroscopic analyses coupled with chemical degradation and they were also evaluated for the cy...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2009.12.008
更新日期:2010-07-01 00:00:00
abstract::The species from Alangium have been used as folk medicine to treat rheumatism, skin diseases, diabetes by the people of Southeast Asia. Previous phytochemical studies have shown this genus are rich sources of alkaloids, glycosides, and terpenoids, which have attracted considerable attention of many researchers due to ...
journal_title:Fitoterapia
pub_type: 杂志文章,评审
doi:10.1016/j.fitote.2020.104773
更新日期:2020-11-01 00:00:00
abstract::Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of bergamot extract (BPF) in diet-induced hyperlipemia in Wistar rats and in 237 patients suffering from hyperlipemia either associated or not with hyperglycaemia. BPF, given orally for 30 days...
journal_title:Fitoterapia
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fitote.2010.10.014
更新日期:2011-04-01 00:00:00
abstract::Eighteen alkaloids were detected in the bark, leaves, wood and roots of Peumus boldus, including traces of secoboldine, N-methylsecoboldine (boldine methine), glaucine and norreticuline, not reported previously as constituents of this species. Using appropriate standards, we quantified thirteen of them by UHPLC-MS/MS....
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2018.02.020
更新日期:2018-06-01 00:00:00
abstract::In the present work, we reported the triterpenoids isolated from n-butanol fraction of Kadsura heteroclita which is a Tujia ethnomedicine with trivial name "Xuetong". This effort resulted in the isolation of six unpresented triterpenoids xuetongsu A-F (1-6), along with five known triterpenoids (7-11). The structures o...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2019.104441
更新日期:2020-01-01 00:00:00
abstract::The gastrointestinal activity of hydroalcoholic extract (HE) of Salvia officinalis was evaluated in a model of ethanol-induced gastric lesion. HE showed excellent activity, with ID(50) 84.0 (54.8-128.9) mg/kg. The acetic acid-induced ulcer and the total acidity of the gastric secretion were also reduced by HE, and, in...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2009.05.015
更新日期:2009-10-01 00:00:00
abstract::Two new compounds, 6-oxo-20-hydroxy-20-epi-tingenol (1) and 2R*,3R*,5S*-trihydroxy-6R*-nonadecyltetrahydropyran-4-one (2), were isolated from the pericarp of Glyptopetalum sclerocarpum along with other 10 constituents. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2004.04.012
更新日期:2004-09-01 00:00:00
abstract::Fourteen pregnane-type steroidal alkaloids were isolated from the ethanolic extracts of whole Sarcococca hookeriana var. digyna plants. Their structures were elucidated on the basis of spectral data. Three of them were identified as new steroidal alkaloids: (S)-20-(N,N-dimethylamino)-16α,17α-epoxy-3β-methoxy-pregn-5-e...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2013.04.010
更新日期:2013-09-01 00:00:00
abstract::The isolation of a new flavan, 5,7,4'-trihydroxy-8-ethoxycarbonylflavan (1), from the root of Daphne odora var. atrocaulis is reported. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2004.09.014
更新日期:2004-12-01 00:00:00
abstract::Four known flavonoids were isolated from the aerial parts of Salvia moorcroftiana. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(99)00109-4
更新日期:2000-02-01 00:00:00
abstract::A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to identify and quantify the camptothecin quaternary derivative CPT8 for application in pharmacokinetics and tissue distribution studies. Rat plasma and tissue samples were extracted with methanol by using camptothecin as the internal sta...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2013.06.012
更新日期:2013-10-01 00:00:00
abstract::Investigation of the dichloromethane extract of the stem of Filicium decipiens yielded a new natural product, 24-norneohopa-4(23),22(29)-diene-3beta,6beta,7beta-triol 7-caffeate (1). ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(01)00296-9
更新日期:2001-11-01 00:00:00