Abstract：
:Five new 2-(2-phenylethyl)chromone derivatives (1-5), along with eleven known compounds (6-16) were isolated from Chinese agarwood. Their structures were elucidated by spectroscopic data (NMR, UV, IR, and MS) analyses and comparison of their spectroscopic and physical data with the literature values. The absolute configurations of 2-4 were determined by electronic circular dichroism (ECD) calculations. Compounds 2-4, 11, 12, and 15 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells with IC50 values in the range 1.6-7.3μM.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Huo HX,Gu YF,Sun H,Zhang YF,Liu WJ,Zhu ZX,Shi SP,Song YL,Jin HW,Zhao YF,Tu PF,Li Jdoi
10.1016/j.fitote.2017.02.009subject
Has Abstractpub_date
2017-04-01 00:00:00pages
49-55eissn
0367-326Xissn
1873-6971pii
S0367-326X(17)30141-7journal_volume
118pub_type
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