Abstract:
:Traditional Indonesian medicinal plants were screened for their inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and for the antioxidant activity through the evaluation of free radical scavenging effect and reducing power. The results of screening indicated that 50 methanolic extracts inhibited (>50%) lipopolysaccharides (LPS)-induced NO release from RAW264.7 cells at 50 microg/ml, with 18 having greater than 100% inhibition. At 200 microg/ml, 61 methanol extracts exhibited inhibitory activity (>50%), with 45 showing greater than 100% inhibition. In addition, the free radical scavenging effects of 6 methanolic extracts were found to be more than 50% for extract concentration of 0.5 mug/ml. The results indicate that the extracts contain active compounds that inhibit NO release and scavenge free radical.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Choi EM,Hwang JKdoi
10.1016/j.fitote.2004.11.010keywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
194-203issue
2eissn
0367-326Xissn
1873-6971pii
S0367-326X(04)00266-7journal_volume
76pub_type
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