Honeybush (Cyclopia sp.) - a rich source of compounds with high antimutagenic properties.

abstract：:20(R)-25-hydroxyprotopanaxadiol (25-OH-PPD) is a natural compound showing a variety of anti-tumor effects. In an attempt to search for a new anti-cancer compound with higher antitumor activities, we designed and synthesized a series of 25-OH-PPD derivatives. Cytotoxicity assay of these derivatives towards MCF-7, A549,...

journal_title：Fitoterapia

authors： Lv L,Lu J,Zhang H,Wang X,Su G,Piao H,Zhao Y

更新日期：2019-09-01 00:00:00

abstract：:The plants of genus Toona are well known for diverse limonoid secondary metabolites, while polyacetylenes are rarely found from Toona species. In this work, six new polyacetylenes toonasindiynes A-F (1-6) and six known analogues (7-12) were isolated from the root bark of Toona sinensis. Their structures and absolute c...

journal_title：Fitoterapia

authors： Xu WJ,Li JH,Zhou MM,Luo J,Jian KL,Tian XM,Xia YZ,Yang L,Luo J,Kong LY

更新日期：2020-10-01 00:00:00

abstract：:A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to identify and quantify the camptothecin quaternary derivative CPT8 for application in pharmacokinetics and tissue distribution studies. Rat plasma and tissue samples were extracted with methanol by using camptothecin as the internal sta...

journal_title：Fitoterapia

authors： Li Q,Zhu Q,Zhang X,Hua C,Deng X,Zhao T,Sun B

更新日期：2013-10-01 00:00:00

abstract：:Oil production from the seeds of Camellia oleifera Abel. causes a great waste of shells which contain a lot of bioactive components. The aim of this research was to isolate flavonoid from the shells of C. oleifera Abel. and evaluate its uses. The shells were extracted by 70% methanol, hydrolyzed by 2M hydrochloric aci...

journal_title：Fitoterapia

authors： Ye Y,Guo Y,Luo YT,Wang YF

更新日期：2012-12-01 00:00:00

abstract：:Total sennosides concentration is a very important factor when rhubarb and senna will be used as crude drugs. However, one-step analytical technique for total sennosides has not been reported except HPLC. An enzyme-linked immunosorbent assay (ELISA) for total sennosides concentration by using the combination of anti-s...

journal_title：Fitoterapia

authors： Morinaga O,Uto T,Sakamoto S,Tanaka H,Shoyama Y

更新日期：2009-01-01 00:00:00

abstract：:A new altersolanol derivative, 4-dehydroxyaltersolanol A (9), along with two known sesquiterpenoids, (S)-7'-hydroxyabscisic acid (7) and (S)-abscisic acid (8) were obtained from the endophytic fungus, Nigrospora oryzae, isolated from leaves of Combretum dolichopetalum. The host plant yielded six known compounds includ...

journal_title：Fitoterapia

authors： Uzor PF,Ebrahim W,Osadebe PO,Nwodo JN,Okoye FB,Müller WE,Lin W,Liu Z,Proksch P

更新日期：2015-09-01 00:00:00

abstract：:Thuja occidentalis L. is indigenous for Northern America and commonly cultivated in Europe. Raw materials obtained from this tree are widely applied in the ethnomedicine and phytotherapy of numerous ailments, incl. scurvy, cystitis, rheumatism and cancer. Despite wide medicinal applications of Thuja occidentalis, stil...

journal_title：Fitoterapia

authors： Pudełek M,Catapano J,Kochanowski P,Mrowiec K,Janik-Olchawa N,Czyż J,Ryszawy D

更新日期：2019-04-01 00:00:00

abstract：:Bioassay-directed separation of the chloroform extracts from the air-dried aerial part of Alhagi pseudalhagi (M.B.) led to the isolation of a new isoflavonolignan (1), together with five known isoflavones (2-6) (Fig. 1). Their structures were identified on the basis of spectral analysis of NMR, MS, IR, UV and CD spect...

journal_title：Fitoterapia

authors： Li N,Zhang G,Xiong Y,Makhabel B,Li X,Jia X

更新日期：2010-12-01 00:00:00

abstract：:A new sulfur-containing iridoid glucoside, named paederoside B, was isolated from the stems of Paederia scandens. The structure of the new compound was elucidated as paederosidyl paederosidate by spectral evidence. ...

journal_title：Fitoterapia

authors： Zou X,Peng S,Liu X,Bai B,Ding L

更新日期：2006-07-01 00:00:00

abstract：:A simple, sensitive and accurate liquid chromatographic method with photodiode-array detection was developed for determination of dehydroevodiamine with detection wavelength at 368 nm and column temperature at 30 degrees C. The separation was carried out on an Agilent Zorbax SB-C(18) column (250 mm x 4.6 mm, 5 microm)...

journal_title：Fitoterapia

authors： Zhao Y,Zhou X,Chen HG,Gong XJ,Cai ZW,Zhou CY

更新日期：2009-10-01 00:00:00

abstract：:The methanol extract and four triterpenoids isolated from the seeds of Caesalpinia bonducella showed a wide range of inhibiting activity against both gram-positive and gram-negative bacteria. ...

journal_title：Fitoterapia

authors： Saeed MA,Sabir AW

更新日期：2001-11-01 00:00:00

abstract：:Four new C18-diterpenoid alkaloids, weisaconitines A-D (1-4), were isolated from Aconitum weixiense. Based on extensive UV, IR, MS, 1D and 2D NMR analyses, their structures were elucidated as 8-O-ethyldolaconine (1), 4-demethylgenicunine B (2), 14-oxoaconosine (3), and 8-O-ethylaconosine (4). The analgesic activity of...

journal_title：Fitoterapia

authors： Zhao DK,Ai HL,Zi SH,Zhang LM,Yang SC,Guo HC,Shen Y,Chen YP,Chen JJ

更新日期：2013-12-01 00:00:00

abstract：:More attention was paid to the anti-tumor activity of Rhizoma Paridis (RP) recently, of which the wild resource was decreased significantly. This study was aimed to elucidate the chemical characteristics of Paris fargesii var. brevipetala (PFB) that may be administrated as alternate resource of legal RP. A HPLC-ELSD m...

journal_title：Fitoterapia

authors： Wen F,Yin H,Chen C,Liu X,Xue D,Chen T,He J,Zhang H

更新日期：2012-06-01 00:00:00

abstract：:The phytochemical profile, antioxidant activity and α-glucosidase inhibitory activity of Hypericum scruglii Bacchetta, Brullo et Salmeri and Hypericum hircinum L. were analyzed and compared to those of the best-known Hypericum perforatum L. Samples were prepared using three different extraction methods (maceration in ...

journal_title：Fitoterapia

authors： Mandrone M,Scognamiglio M,Fiorentino A,Sanna C,Cornioli L,Antognoni F,Bonvicini F,Poli F

更新日期：2017-07-01 00:00:00

abstract：:The aim of the present research was to establish a comprehensive strategy to identify the metabolites of isoimperatorin after biotransformation with rat liver microsomes in vitro, and further describe metabolic kinetic characteristics of isoimperatorin and its main metabolites. Utilizing liquid chromatography with tim...

journal_title：Fitoterapia

authors： Chen TL,Zhang YB,Xu W,Kang TG,Yang XW

更新日期：2014-03-01 00:00:00

abstract：:Two new alkaloids were isolated from the bark of Sarcomelicope megistophylla. Cyclomegistine B (1), a new quinolone alkaloid, that possesses a rare cyclobuta[b]quinoline ring system and sarcomejine B (2) which is a quinolone alkaloid with an unusual side chain. The structure of both compounds was elucidated on the bas...

journal_title：Fitoterapia

authors： Mitaku S,Fokialakis N,Magiatis P,Tillequin F

更新日期：2007-02-01 00:00:00

abstract：:Besides the unquestionable positive effects of solar exposure for human health, UV rays have been widely investigated for toxicology aspects related to excessive UVB and UVA doses, which involve sunburns, skin aging, DNA skin damage and tumorigenesis. At present, synthetic and mineral sunscreens are used to protect ag...

journal_title：Fitoterapia

authors： Radice M,Manfredini S,Ziosi P,Dissette V,Buso P,Fallacara A,Vertuani S

更新日期：2016-10-01 00:00:00

abstract：:The present study was designed to verify whether frutalin (FTL) affords gastroprotection against the ethanol-induced gastric damage and to examine the underlying mechanism(s). Gastric damage was induced by intragastric administration of 0.2 ml of ethanol (96%). Mice in groups were pretreated with FTL (0.25, 0.5 and 1 ...

journal_title：Fitoterapia

authors： de Vasconcellos Abdon AP,Coelho de Souza G,Noronha Coelho de Souza L,Prado Vasconcelos R,Araújo Castro C,Moreira Guedes M,Pereira Lima RC Jr,de Azevedo Moreira R,de Oliveira Monteiro-Moreira AC,Rolim Campos A

更新日期：2012-04-01 00:00:00

abstract：:Ten new highly oxygenated lanostane triterpenoids, stereinones A-J (1-10), were isolated from the fruiting bodies of the basidiomycete Stereum sp. Compounds 3 and 4 are structurally characterized as intact lanostane-type triterpenoids containing unusual 1,2-diketone functionality at C-11 and C-12, while compound 10 is...

journal_title：Fitoterapia

authors： Yao JN,Chen L,Chen HP,Zhao ZZ,Zhang SB,Huang Y,Tang Y,Isaka M,Li ZH,Feng T,Liu JK

更新日期：2018-03-01 00:00:00

abstract：:Three new clerodane type diterpenoids (2-4), together with one known analogues (1), were isolated from the tuberous roots of Tinospora sagittata (Oliv.) Gagnep. Compound 3 is an unusual clerodane diterpenoid with the carbonyl functionality at C-3, which represents the first example from this diterpenoid compounds clas...

journal_title：Fitoterapia

authors： Zhang G,Ma H,Hu S,Xu H,Yang B,Yang Q,Xue Y,Cheng L,Jiang J,Zhang J,Wang F,Zhang Y

更新日期：2016-04-01 00:00:00

abstract：:The flavonoids are a heterogeneous group of ubiquitous plant polyphenols that abound in the human diet and are endowed with several biological activities, including immunomodulating and antioxidant activities. The bioactivity of flavonoids is tightly correlated with their chemical structure and action mechanisms, most...

journal_title：Fitoterapia

authors： Ielpo MT,Basile A,Miranda R,Moscatiello V,Nappo C,Sorbo S,Laghi E,Ricciardi MM,Ricciardi L,Vuotto ML

更新日期：2000-08-01 00:00:00

abstract：:Various parts of Derris elliptica, Derris indica and Derris trifoliata on fractionation with a number of solvents (petrol, dichloromethane, ethyl acetate, butanol and methanol) gave fractions which demonstrated a varied level of broad spectrum antibacterial activity. Good activity was exhibited by the methanol fractio...

journal_title：Fitoterapia

authors： Khan MR,Omoloso AD,Barewai Y

更新日期：2006-06-01 00:00:00

abstract：:Rubus ideaus L., a member of the Rosaceae family, is popular for its distinctive flavor and attractive red color. In order to explore the functional factors possibly presented in the fruit, seven new benzofuran neolignans (1a/1b-3a/3b and 4b), together with one known neolignan 4a, were isolated from the fruit of R. id...

journal_title：Fitoterapia

authors： Zhou L,Xi YF,Wang W,Lin B,Wang XB,Huang XX,Song SJ

更新日期：2018-06-01 00:00:00

abstract：:Four new taraxerane triterpenoids, 1β,3β-dihydroxy-11α,12α-oxidotaraxerane (1), 28-hydroxy-11α,12α-oxidotaraxerane-3-one (2), 3β-hydroxy-11α,12α-oxidotaraxerane-28-al (3), and 3-O-acetyl-11α,12α-oxidotaraxerane-28-al (4), together with three known compounds 3β-hydroxy-11α,12α-oxidotaraxerane (5), 3β,28-dihydroxy-11α,1...

journal_title：Fitoterapia

authors： Hu J,Shi X,Chen J,Huang H,Zhao C

更新日期：2012-01-01 00:00:00

abstract：:A new compound, 3beta,25-epoxy-3alpha-hydroxy-22beta-isobutanoyloxyolean-12-ene-28-oic acid (1), and two known triterpenoids lantanilic acid (2) and camaric acid (3) were isolated from the stem and leaves of Lantana cujabensis. Their structures were elucidated by spectroscopic methods. The ethanol extracts did not sho...

journal_title：Fitoterapia

authors： Okunade AL,Lewis WH

更新日期：2004-06-01 00:00:00

abstract：:Three new sesquiterpenoids, peniterpenoids A - C (1-3), together with six known metabolites (4-9) were isolated from an entomogenous fungus Penicillium janthinellum (LB1.20090001) collected from a wheat cyst nematode. The structures of the new compounds were elucidated based on NMR and HRESIMS spectroscopic analyses. ...

journal_title：Fitoterapia

authors： Liu S,Fan W,Ren J,Wang W,Liu X,Liang Y,Wei T,Li E

更新日期：2021-01-01 00:00:00

abstract：:Three new mixed terpenoids, tricycloalternarenes (TCAs) F-H (1-3), together with ten known tricycloalternarenes (4-13), were isolated from the Czapek's culture of an endophytic fungus Ulocladium sp. Their structures were identified by extensive spectroscopic experiments (NMR and MS) and comparison with literature data...

journal_title：Fitoterapia

authors： Wang QX,Bao L,Yang XL,Guo H,Ren B,Guo LD,Song FH,Wang WZ,Liu HW,Zhang LX

更新日期：2013-03-01 00:00:00

abstract：:Two new natural products, 5-O-[β-D-apiofuranosyl-(1→6)-β-d-glucopyranosyl]-1-isoindolinone (1) as well as N-(2E)-3-[(2S,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]acryloylglycine (2), along with four known compounds (3-6), were isolated from the methanolic extract of Co...

journal_title：Fitoterapia

authors： Fouseki MM,Damianakos H,Karikas GA,Roussakis C,P Gupta M,Chinou I

更新日期：2016-12-01 00:00:00

abstract：:Five new megastigmane glycosides, urenalobasides A-E (1-5), together with 11 known ones (6-16) were isolated from Urena lobata. Their structures were determined by extensive spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism method. Compounds 1 and 2 are ...

journal_title：Fitoterapia

authors： Su C,Qi B,Wang J,Ding N,Wu Y,Shi XP,Zhu ZX,Liu X,Wang XH,Zheng J,Tu PF,Shi SP

更新日期：2018-06-01 00:00:00

abstract：:Six new monoterpenoid indole alkaloids, 19(E)-9-demethoxy-16-dehydroxylchitosenine-17-O- β-d-glucopyranoside (1), 19(E)-9,10-didemethoxy-16-dehydroxylchitosenine-17-O-β-d-gluco-pyranoside (2), 19(E)-9,10-didemethoxy-16-dehydroxyl-11-methoxychitosenine (3), 19(E)-9,10-didemethoxy-16-dehydroxyl-11-methoxychitosenine-17-...

journal_title：Fitoterapia

authors： Yang WX,Chen YF,Yang J,Huang T,Wu LL,Xiao N,Hao XJ,Zhang YH

更新日期：2018-01-01 00:00:00