Antineoplastic activity of selected constituents of Duguetia glabriuscula.

Abstract:

:The cytotoxic effects of seven constituents isolated from Duguetia glabriuscula were evaluated against Hep2 human larynx carcinoma cells. The cytotoxicity exhibited by beta-sitosterol was as strong as that of cis-platin. (+)-Alloaromadendran-10,14beta-diol caused inhibition of cellular growth with IC50 values lower than 25 microg/ml, a feature that was considered as revealing significant activity. Polycarpol showed borderline cytotoxicity, whereas the other compounds were inactive.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Matos MF,Leite LI,Brustolim D,de Siqueira JM,Carollo CA,Hellmann AR,Pereira NF,da Silva DB

doi

10.1016/j.fitote.2006.01.013

keywords:

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

227-9

issue

3

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(06)00041-4

journal_volume

77

pub_type

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