Abstract:
:The aqueous extract of Crinum giganteum given intraperitoneally at doses of 6.25, 12.5 and 25 mg/kg in rats prolonged the duration of pentobarbital sleeping time and in mice reduced spontaneous motor activity, decreased the exploratory activity and attenuated amphetamine-induced stereotype behavior. The intraperitoneal and oral preliminary LD(50) in mice were found to be 627 and 1468 mg/kg, respectively. The data obtained suggest that the aqueous extract of C. giganteum contains some biologically active principles with sedative activity.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Amos S,Binda L,Akah P,Wambebe C,Gamaniel Kdoi
10.1016/s0367-326x(02)00287-3keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
23-8issue
1-2eissn
0367-326Xissn
1873-6971pii
S0367326X02002873journal_volume
74pub_type
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