Central inhibitory activity of the aqueous extract of Crinum giganteum.

Abstract:

:The aqueous extract of Crinum giganteum given intraperitoneally at doses of 6.25, 12.5 and 25 mg/kg in rats prolonged the duration of pentobarbital sleeping time and in mice reduced spontaneous motor activity, decreased the exploratory activity and attenuated amphetamine-induced stereotype behavior. The intraperitoneal and oral preliminary LD(50) in mice were found to be 627 and 1468 mg/kg, respectively. The data obtained suggest that the aqueous extract of C. giganteum contains some biologically active principles with sedative activity.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Amos S,Binda L,Akah P,Wambebe C,Gamaniel K

doi

10.1016/s0367-326x(02)00287-3

keywords:

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

23-8

issue

1-2

eissn

0367-326X

issn

1873-6971

pii

S0367326X02002873

journal_volume

74

pub_type

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