Studies on the immunomodulatory activity of flavonoidal fraction of Tephrosia purpurea.

Abstract:

:The flavonoid fraction of Tephrosia purpurea (FFTP) was studied for its effect on cellular and humoral functions and on macrophage phagocytosis in mice. Oral administration of FFTP (10-40 mg/kg) significantly inhibited sheep red blood cells (SRBC)-induced delayed-type hypersensitivity reactions. It also produced a significant, dose-related decrease in sheep erythrocyte-specific haemagglutination antibody titre. However, the fraction failed to show a significant change in the macrophage phagocytic activity. The results obtained indicate the ability of the flavonoidal fraction of T. purpurea to modulate both the cell-mediated and the humoral components of the immune system.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Damre AS,Gokhale AB,Phadke AS,Kulkarni KR,Saraf MN

doi

10.1016/s0367-326x(03)00042-x

keywords:

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

257-61

issue

3

eissn

0367-326X

issn

1873-6971

pii

S0367326X0300042X

journal_volume

74

pub_type

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