Sesquiterpenes from Vladimiria souliei and their inhibitory effects on NO production.

abstract：:The Src-homology 2 domain-containing phosphatase 2 (SHP2), encoded by PTPN11, has been reported oncogenic tyrosine phosphatase associated with various tumors and played critical roles in many cell signaling events. Targeting SHP2 by small molecules may be a promising way for cancer therapy. Herein, a new abietane dite...

journal_title：Fitoterapia

authors： Liu DM,Cao ZX,Yan HL,Li W,Yang F,Zhao WJ,Diao QC,Tan YZ

更新日期：2020-03-01 00:00:00

abstract：:A new guanidine alkaloid, millaurine A (1), was isolated from the methanol extract of the seeds of Millettia laurentii. The structure of the new compound was elucidated on the basis of spectral analysis. ...

journal_title：Fitoterapia

authors： Ngamga D,Fanso Free SN,Tane P,Fomum ZT

更新日期：2007-04-01 00:00:00

abstract：:Two new glycosides, 2-methyl-L-erythritol-4-O-(6-O-trans-sinapoyl)-β-D-glucopyranoside (1) and 2-methyl-L-erythritol-1-O-(6-O-trans-sinapoyl)-β-D-glucopyranoside (2), along with two known triterpenoids (3-4), four quinic acid derivatives (5-8) and one flavonoid (9) were isolated from the fruit of Gardenia jasminoides....

journal_title：Fitoterapia

authors： Yang L,Peng K,Zhao S,Zhao F,Chen L,Qiu F

更新日期：2013-09-01 00:00:00

abstract：:Four pairs of racemic phenylpropanoids (1a/1b-4a/4b), including five new compounds (1a/1b, 2a, 3a, and 4a) were obtained from the root barks of Ailanthus altissima (Mill.) Swingle. Their structures were determined by comprehensive spectroscopic analyses. The absolute configurations of the enantiomers were determined b...

journal_title：Fitoterapia

authors： Yan ZY,Chen JJ,Duan ZK,Yao GD,Lin B,Wang XB,Huang XX,Song SJ

更新日期：2018-10-01 00:00:00

abstract：:Eight new dihydrobenzofuran neolignans, pinnatifidanin C I-VIII (1-8), together with two known analogs (9-10) were isolated from the seeds of Crataegus pinnatifida. Their structures were elucidated by spectroscopic analyses, especially 1D, 2D NMR and CD spectra. The cytotoxic activities of all isolates against human c...

journal_title：Fitoterapia

authors： Huang XX,Zhou CC,Li LZ,Peng Y,Lou LL,Liu S,Li DM,Ikejima T,Song SJ

更新日期：2013-12-01 00:00:00

abstract：:Escin exerts potent glucocorticoid-like anti-inflammatory effects. The aim of this study was to investigate whether the anti-inflammatory effect of escin is through the up-regulation of glucocorticoids and if escin induces pathological changes in immune organs. Mice were administrated with escin intravenously for 7 da...

journal_title：Fitoterapia

authors： Zhang L,Wang H,Fan H,Wang T,Jiang N,Yu P,Fu F

更新日期：2011-09-01 00:00:00

abstract：:Euphorbia aellenii Rech. f. (Euphorbiaceae) afforded a cytotoxic chloroform fraction from which two new esters of 6(17)-epoxylathyrol were identified (1 and 2). The structure of these compounds was elucidated by spectroscopic methods. ...

journal_title：Fitoterapia

authors： Ayatollahi AM,Ghanadian M,Afsharypuor S,Choudhary MI,Kobarfard F,Rahmati M

更新日期：2010-10-01 00:00:00

abstract：:Ten new geranylated 2-arylbenzofuran derivatives, including two monoterpenoid 2-arylbenzofurans (1 and 2), two geranylated 2-arylbenzofuran enantiomers (3a and 3b), and six geranylated 2-arylbenzofurans (4-9), along with four known 2-arylbenzofurans (10-13) were isolated from the root bark of Morus alba var. tatarica....

journal_title：Fitoterapia

authors： Zhang YL,Luo JG,Wan CX,Zhou ZB,Kong LY

更新日期：2014-01-01 00:00:00

abstract：:Various parts of Derris elliptica, Derris indica and Derris trifoliata on fractionation with a number of solvents (petrol, dichloromethane, ethyl acetate, butanol and methanol) gave fractions which demonstrated a varied level of broad spectrum antibacterial activity. Good activity was exhibited by the methanol fractio...

journal_title：Fitoterapia

authors： Khan MR,Omoloso AD,Barewai Y

更新日期：2006-06-01 00:00:00

abstract：:Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of 0.25-1mg/ml. It inhibited hydrol...

journal_title：Fitoterapia

authors： Liu R,Zhang J,Liu W,Kimura Y,Zheng Y

更新日期：2010-12-01 00:00:00

abstract：AIM:The current study was designed to explore the mechanism of the prokinetic activity of Gentiopicroside (Ge), from Gentiana macrophylla Pall which is widely used to strengthen gastric motility in clinic. METHODS:Gastrointestinal motility disorder rats were induced by stress stimulation and the rats were treated with...

journal_title：Fitoterapia

authors： Ruan M,Yu B,Xu L,Zhang L,Long J,Shen X

更新日期：2015-06-01 00:00:00

abstract：:The high edible oil content of Xanthoceras sorbifolia Bunge seeds contributes to its economic value. In this study, we analysed the barrigenol-like triterpenoids derived from X. sorbifolia husks. We also identified anti-tumour agents that could enhance the health benefits and medicinal value of X. sorbifolia. We isola...

journal_title：Fitoterapia

authors： Wang D,Su D,Yu B,Chen C,Cheng L,Li X,Xi R,Gao H,Wang X

更新日期：2017-01-01 00:00:00

abstract：:Five new 2-(2-phenylethyl)chromone derivatives (1-5), along with eleven known compounds (6-16) were isolated from Chinese agarwood. Their structures were elucidated by spectroscopic data (NMR, UV, IR, and MS) analyses and comparison of their spectroscopic and physical data with the literature values. The absolute conf...

journal_title：Fitoterapia

authors： Huo HX,Gu YF,Sun H,Zhang YF,Liu WJ,Zhu ZX,Shi SP,Song YL,Jin HW,Zhao YF,Tu PF,Li J

更新日期：2017-04-01 00:00:00

abstract：:Two new prenylated 4-phenylcoumarins, named kielcoumarin A (1) and kielcoumarin B (2) together with three known compounds, mammea B/BA (3), mammea B/BA cyclo F (4) and ferruol A (5), were obtained from stems and roots of Kielmeyera argentea (Calophyllaceae). Their structures were elucidated based on spectroscopic data...

journal_title：Fitoterapia

authors： Boness HVM,Santos NAS,Costa IB,Queiroz CKL,Marques EJ,El-Bachá RS,Cruz FG

更新日期：2021-01-27 00:00:00

abstract：:Oral treatment with the water extracts of Scoparia dulcis whole aerial parts, at doses of 50, 100 and 200 mg/kg, dose dependently inhibited the indomethacin-induced gastric damages in rats. ...

journal_title：Fitoterapia

authors： Babincová M,Schronerová K,Sourivong P

更新日期：2008-12-01 00:00:00

abstract：:Hispolon was the main antitumor active ingredient in Phellinus sensu lato species. In order to confirm the dual regulating estrogenic ingredient and obtain more effective natural estrogen replacement drugs, hispolon was separated from Phellinus lonicerinus (Bond.) Bond. et sing. Hispolon exhibited significant anti-pro...

journal_title：Fitoterapia

authors： Wang J,Hu F,Luo Y,Luo H,Huang N,Cheng F,Deng Z,Deng W,Zou K

更新日期：2014-06-01 00:00:00

abstract：:Smyrnium olusatrum (Apiaceae), well known as wild celery, is a biennal celery-scented plant used for many centuries as a vegetable, then abandoned after the introduction of celery. In the present work, the essential oil obtained from inflorescences and the amounts of its main constituents isofuranodiene, curzerene and...

journal_title：Fitoterapia

authors： Quassinti L,Maggi F,Barboni L,Ricciutelli M,Cortese M,Papa F,Garulli C,Kalogris C,Vittori S,Bramucci M

更新日期：2014-09-01 00:00:00

abstract：:Five new sesquiterpenes (1-5) along with ten known ones were isolated from the heartwood of Dalbergia odorifrea T. Chen. Their structures were determined by spectroscopic techniques including MS, UV, IR, 1D and 2D NMR. Bioassay results showed that compounds 1 and 9 had inhibitory effect on Candida albicans, and compou...

journal_title：Fitoterapia

authors： Wang H,Dong WH,Zuo WJ,Liu S,Zhong HM,Mei WL,Dai HF

更新日期：2014-06-01 00:00:00

abstract：:Ganoderma cochlear, as edible and medicinal fungus, has long been used to prevent and treat various diseases. As our continuously phytochemical investigation of this fungus, a HPLC-UV-guided method led to the isolation of nine previously undescribed aromatic meroterpenoids with different ring systems, including six pa...

journal_title：Fitoterapia

authors： Peng X,Wang X,Chen L,Yang H,Li L,Lu S,Zhou L,Qiu M

更新日期：2018-06-01 00:00:00

abstract：:The last few decades have seen an alarming rise in fungal infections, which currently represent a global health threat. Despite extensive research towards the development of new antifungal agents, only a limited number of antifungal drugs are available in the market. The routinely used polyene agents and many azole an...

journal_title：Fitoterapia

authors： Shreaz S,Wani WA,Behbehani JM,Raja V,Irshad M,Karched M,Ali I,Siddiqi WA,Hun LT

更新日期：2016-07-01 00:00:00

abstract：:Ten new tricyclic prezizaane types sesquiterpenoids (1-10) were isolated from ethyl ether extract of agarwood originated from Aquilaria sp. Their structures were unambiguously elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of the new prezizaenes 1, 2 and 4 was d...

journal_title：Fitoterapia

authors： Yang YL,Li W,Wang H,Yang L,Yuan JZ,Cai CH,Chen HQ,Dong WH,Ding XP,Jiang B,Mándi A,Kurtán T,Mei WL,Dai HF

更新日期：2019-10-01 00:00:00

abstract：:Investigators and sponsors of dietary supplement research need to know the relevant regulatory requirements and how to comply with them. This brief review describes how research on dietary supplements is regulated by FDA. In general, whether an FDA sanctioned Investigational New Drug (IND) application is required for ...

journal_title：Fitoterapia

authors： Chen ST

更新日期：2011-01-01 00:00:00

abstract：:Four new cycloartane triterpenoids, 1α,3β-dihydroxy-16-keto-24(31)-en-cycloartane (1), 31-methoxyl-passifloic acid (2), cyclopassifloside XIV (3), and cyclopassifloside XV (4), together with six known compounds (5-10) were isolated from Passiflora edulis Sims. Their structures were elucidated on the basis of extensive...

journal_title：Fitoterapia

authors： Xu FQ,Wang N,Fan WW,Zi CT,Zhao HS,Hu JM,Zhou J

更新日期：2016-12-01 00:00:00

abstract：:Four meroterpenoids, applanatumols F (1), H (3), I (2), and lingzhiol (4) were isolated from the 95% EtOH extract of the fruiting bodies of Ganoderma sinense. Their structures were established on the basis of NMR spectroscopic analyses, optical rotatory dispersion data, ECD spectra, and X-ray crystallography. Compound...

journal_title：Fitoterapia

authors： Gao S,Zhang P,Zhang C,Bao F,Li H,Chen L

更新日期：2018-11-01 00:00:00

abstract：:Six Patagonian plants were screened for proteolytic activity: Colliguaja integerrima, Euphorbia collina, E. peplus and Stillingia patagonica (Euphorbiaceae), Philibertia gilliesii (Asclepiadaceae) and Grindelia chiloensis (Asteraceae). P. gilliesii extracts showed the highest specific activity, followed by S. patagoni...

journal_title：Fitoterapia

authors： Sequeiros C,López LM,Caffini NO,Natalucci CL

更新日期：2003-09-01 00:00:00

abstract：:We investigated the effect of caffeoylserotonin (CaS) on THP-1 monocyte migration and adhesion to fibronectin in response to MCP-1. CaS decreased monocyte adhesion and migration induced by MCP-1, together with CCR2 expression and α5β1 integrin, and activated β1 integrin expression on the cell surface. CaS also inhibit...

journal_title：Fitoterapia

authors： Yoon JH,Kim HE,Choi JY,Bae HJ,Lee SG

更新日期：2012-12-01 00:00:00

abstract：:Samarones A-D (1-4), four new acylphloroglucinol derivatives bearing a C17 alkyl side chain, along with five known analogues (5-9), were isolated from the leaves of Syzygium samarangense. Their structures were characterized on the basis of extensive spectroscopic methods including HR-ESI-MS/MS analysis. The cytotoxic ...

journal_title：Fitoterapia

authors： Yang J,Su JC,Lei XP,Huang XJ,Zhang DM,Ye WC,Wang Y

更新日期：2018-09-01 00:00:00

abstract：:Six new triterpenoids, pseudolarins A-F (1-6), were isolated from the twigs of Pseudolarix amabilis, together with four known triterpenoids (7-10) and five known diterpenoids (11-15). Their structures were determined by extensive spectroscopic analysis, and the absolute configuration of 1 was assigned by single-crysta...

journal_title：Fitoterapia

authors： Lei C,Huang QH,Zhao T,Wang PP,Li JY,Li J,Hou AJ

更新日期：2019-11-01 00:00:00

abstract：:One new resveratrol analogue, 1-(3',4',5'-trimethoxyphenyl)-2-methoxy-2-(4″-methoxyphenyl)-ethane-1-ol (1), and two new prenylisoflavones, 4'-hydroxy-5,7-dimethoxy-6-(3-methyl-2-butenyl)-isoflavone (2), and derrubon 5-methyl ether (3), together with 17 known compounds including one new natural product, 5,7-dihydroxy-3...

journal_title：Fitoterapia

authors： Zhang HX,Lunga PK,Li ZJ,Dai Q,Du ZZ

更新日期：2014-06-01 00:00:00

abstract：:Thirty-five crude extracts from 11 Panamanian plants, distributed in 10 genera and five families, were evaluated for their in vitro cytotoxicity. Four extracts exhibited an inhibition of cellular growth at IC(50) values lower than 25 microg/ml which was considered a significant activity. ...

journal_title：Fitoterapia

authors： Calderón AI,Terreaux C,Gupta MP,Hostettmann K

更新日期：2003-06-01 00:00:00