Abstract：
:Two new glycosides, 2-methyl-L-erythritol-4-O-(6-O-trans-sinapoyl)-β-D-glucopyranoside (1) and 2-methyl-L-erythritol-1-O-(6-O-trans-sinapoyl)-β-D-glucopyranoside (2), along with two known triterpenoids (3-4), four quinic acid derivatives (5-8) and one flavonoid (9) were isolated from the fruit of Gardenia jasminoides. Their structures were elucidated through MS and 2D NMR experiments (HMQC and HMBC). Inhibitory effects of the isolated compounds on nitric oxide production in lipopolysaccharide-activated macrophages were evaluated. Though 2-methyl-D-erythritol and its glycosides have been reported in a few references, this is the first report about 2-methyl-L-erythritol glycosides. Based on this finding, we propose that 2-methyl-L-erythritol might be a new intermediate in the non-mevalonate biosynthesis of terpenoids.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Yang L,Peng K,Zhao S,Zhao F,Chen L,Qiu Fdoi
10.1016/j.fitote.2013.05.018subject
Has Abstractpub_date
2013-09-01 00:00:00pages
126-30eissn
0367-326Xissn
1873-6971pii
S0367-326X(13)00138-Xjournal_volume
89pub_type
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