Cytotoxic triterpene glycosides from the sea cucumber Pseudocolochirus violaceus.

Abstract:

:A new triterpene glycoside (1) along with the known intercedenside B (2) was isolated from the sea cucumber Pseudocolochirus violaceus. Glycoside 1 was elucidated as 3-O-{6-O-sodiumsulfate-3-O-methyl-beta-D-glucopyranosyl-(1-->3)-beta-D-xylopyranosyl-(1-->4)-[beta-D-xylopyranosyl(1-->2)]-beta-D-quinovopyranosyl-(1-->2)-4-O-sodiumsulfate-beta-D-xylopyranosyl}-16beta-acetoxy-holosta-7, 24-diene-3beta-ol on the basis of extensive spectral studies and chemical evidence. Both the glycosides exhibited significant cytotoxicity against cancer cell lines MKN-45 and HCT-116.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Zhang SY,Tang HF,Yi YH

doi

10.1016/j.fitote.2007.02.010

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

283-7

issue

4

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(07)00078-0

journal_volume

78

pub_type

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