Anti-hyperglycemic action of apigenin-6-C-β-fucopyranoside from Averrhoa carambola.

Abstract:

:A stimulatory effect of apigenin-6-C-β-fucopyranoside (1) on glucose uptake was observed when rat soleus muscle was incubated with 1, 10 and 100 μM of this flavonoid glycoside. The presence of specific insulin signaling inhibitors, such as wortmannin, an inhibitor of phosphoinositide 3-kinase (PI3K), RO318220, an inhibitor of protein kinase C (PKC), PD98059, an inhibitor of mitogen-activated protein kinase (MEK), and HNMPA(AM)₃, an insulin receptor tyrosine kinase activity inhibitor showed that apigenin-6-C-β-fucopyranoside triggers different metabolic pathways in skeletal muscle. The oral administration of crude extract, fractions and isolated flavonoids (apigenin-6-C-β-fucopyranoside (1) and apigenin-6-C-(2″-O-α-rhamnopyranosyl)-β-fucopyranoside (2)) from Averrhoa carambola leaves exhibited a potential hypoglycemic activity in hyperglycemic normal rats. Additionally, both flavonoids significantly increased the muscle and liver glycogen content after an acute treatment. The results indicate that A. carambola can be regarded as a potent antihyperglycemic agent with insulin secretagogue and insulin mimetic properties.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Cazarolli LH,Kappel VD,Pereira DF,Moresco HH,Brighente IM,Pizzolatti MG,Silva FR

doi

10.1016/j.fitote.2012.07.003

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

1176-83

issue

7

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(12)00203-1

journal_volume

83

pub_type

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