Abstract：
:The antinociceptive properties of the aqueous extract of Eupatorium buniifolium aerial parts were investigated in chemical and thermal models of nociception in mice. Oral doses of 250 and 500 mg/kg produced an inhibition of 42.3% and 73.9%, respectively, of the abdominal writhes induced by acetic acid in mice. This antinociceptive effect was not reversed by pretreatment with naloxone. In the formalin test, the administration of 500 and 1000 mg/kg p.o. had no effects in the first phase (0-5 min) but produced a dose-dependent analgesic effect on the second phase (15-30 min) with inhibitions of the licking time of 38.9% and 57.3%, respectively. In the hot plate test, no effect was seen at the dose of 500 mg/kg p.o.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Miño J,Muschietti L,Ferraro G,Martino V,Acevedo Cdoi
10.1016/j.fitote.2004.10.009keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
100-3issue
1eissn
0367-326Xissn
1873-6971pii
S0367-326X(04)00237-0journal_volume
76pub_type
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