New steroids and sesquiterpene from Turraea pubescens.

Abstract:

:Four new compounds, including three new steroids (1-3) and one new sesquiterpene (6), and two new natural products (4-5), as well as three known steroids (7-9) were isolated from the twigs of Turraea pubescens. Compounds 3-5 are C₂₂ steroids isolated from the Meliaceae family for the first time. Their structures were elucidated by extensive NMR and MS analyses. Compound 1 exhibited inhibitory activity against lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264.7 cells with an IC₅₀ value of 11.5 μM.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Yuan CM,Tang GH,Wang XY,Zhang Y,Cao MM,Li XH,Li Y,Li SL,Di YT,He HP,Hao XJ,Hua HM

doi

10.1016/j.fitote.2013.07.006

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

119-25

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(13)00177-9

journal_volume

90

pub_type

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