Abstract:
:Phytochemical investigations on Physalis. alkekengi L. var. franchetii, a widespread traditional Chinese medicine, led to the isolation and identification of three new sesquiterpenoids physalisitins A-C (1-3). Their structures were elucidated by NMR and HRESIMS analysis, and their absolute configurations were determined by quantum chemical NMR and ECD calculations, as well as by comparing their optical rotation values with those known analogues. All of the isolated compounds were evaluated for their cyclooxygenase-2 (COX-2) inhibitory activity. Compounds 1-3 dose-dependently inhibited the COX-2 enzyme with IC50 values of 3.22 ± 0.25, 6.35 ± 0.84, and 11.13 ± 1.47 μM, respectively.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Zhang JL,Zhou FF,Li YZ,Feng T,Jiang LL,Jiang RW,Zhang XX,Li XDdoi
10.1016/j.fitote.2020.104470subject
Has Abstractpub_date
2020-03-01 00:00:00pages
104470eissn
0367-326Xissn
1873-6971pii
S0367-326X(19)32341-Xjournal_volume
141pub_type
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