Abstract:
:Ten new tricyclic prezizaane types sesquiterpenoids (1-10) were isolated from ethyl ether extract of agarwood originated from Aquilaria sp. Their structures were unambiguously elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of the new prezizaenes 1, 2 and 4 was determined by single-crystal X-ray diffraction, while TDDFT-ECD method was applied for 6. Compounds 4 and 5 displayed significant inhibitory activities toward α-glucosidase with IC50 values of 0.22 and 1.99 mM, respectively.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Yang YL,Li W,Wang H,Yang L,Yuan JZ,Cai CH,Chen HQ,Dong WH,Ding XP,Jiang B,Mándi A,Kurtán T,Mei WL,Dai HFdoi
10.1016/j.fitote.2019.104301subject
Has Abstractpub_date
2019-10-01 00:00:00pages
104301eissn
0367-326Xissn
1873-6971pii
S0367-326X(19)31058-5journal_volume
138pub_type
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