Abstract：
:Australian native plants have a long history of therapeutic use in indigenous cultures, however, they have been poorly studied scientifically. We analysed the effects of 14 plant derived compounds from the species Pilidiostigma glabrum, Myoporum montanum, Geijera parviflora, and Rhodomyrtus psidioides for their potential wound healing properties by assessing their ability to induce or suppress Collagen I and Collagen III expression in human skin fibroblasts in culture. The compound 7-geranyloxycoumarin was able to significantly increase Collagen I (23.7%, p<0.0002) expression in comparison to control. Significant suppression of Collagen III was observed for the compounds flindersine (11.1%, p<0.02), and (N-acetoxymethyl) flindersine (27%, p<0.00005). The implications of these finding is that these compounds could potentially alter the expression of different collagens in the skin allowing for the potential development of new wound healing therapies and new approaches for treating various skin diseases as well as photo (sun) damaged, and aged skin.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Adams DH,Shou Q,Wohlmuth H,Cowin AJdoi
10.1016/j.fitote.2015.12.010subject
Has Abstractpub_date
2016-03-01 00:00:00pages
45-51eissn
0367-326Xissn
1873-6971pii
S0367-326X(15)30138-6journal_volume
109pub_type
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