Abstract:
:Wedelia (Sphagneticola trilobata, Syn. Wedelia trilobata), a notoriously invasive agricultural weed, can inhibit the growth and development of crops in the field. Eight new eudesmanolides (1-8), along with twelve known congeners (9-20), were isolated and identified from the flowers of Wedelia. Their chemical structures were elucidated through various spectroscopic techniques. The isolates were tested for anti-proliferative activities against HeLa, HepG2, and SGC-7901 tumor cell lines. Most eudesmanolides exhibited significant anti-proliferative activities with good selectivity. Meanwhile, the cells morphology and clonogenic survival assays were observed for compounds 1-3. Moreover, compound 6 displayed obvious anti-neuroinflammatory effect by inhibition of NO production in LPS-induced microglia BV-2 cells with the IC50 value of 11.77 ± 0.83 μM. Hence, this study demonstrated that the eudesmanolides from Wedelia possessed significant antitumor and anti-inflammatory activity, which provided some guides for the further development and a new thinking for its control.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Sun L,Wang Z,Wang Y,Xu J,He Xdoi
10.1016/j.fitote.2019.104452subject
Has Abstractpub_date
2020-04-01 00:00:00pages
104452eissn
0367-326Xissn
1873-6971pii
S0367-326X(19)32309-3journal_volume
142pub_type
杂志文章相关文献
FITOTERAPIA文献大全abstract::The antimicrobial and cytotoxic activities of six lignans isolated from the core and bark acetone extracts of Hibiscus cannabinus have been investigated. Two compounds (2 and 3) showed strong cytotoxic activity against HeLa, Hep-2 and A-549 cell lines while compound 5 showed moderate activity on HeLa cells when they w...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2007.03.010
更新日期:2007-07-01 00:00:00
abstract::The irritant potential of total methanolic extract and five triterpenoids newly isolated from the leaves of Ficus carica investigated by open mouse ear assay. Total methanolic extract, calotropenyl acetate, methyl maslinate and lupeol acetate showed potent and persistent irritant effects. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(02)00127-2
更新日期:2002-08-01 00:00:00
abstract::Successive petroleum ether, dichloromethane and methanol extracts of Ajuga remota aerial parts were tested in vitro for their antifungal activity. The petroleum ether fraction was found to be the most effective against the tested pathogens. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(00)00280-x
更新日期:2001-02-01 00:00:00
abstract::Fractions prepared from the methanol extract of Buchholzia coriacea stem bark exhibited a high concentration-dependent antibacterial and antifungal activity compared to the standard antibiotics, ampicillin and tioconazole. In the brine shrimp lethality (BSL) assay, the methanol extract was found to be non-toxic with a...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(03)00142-4
更新日期:2003-12-01 00:00:00
abstract::More attention was paid to the anti-tumor activity of Rhizoma Paridis (RP) recently, of which the wild resource was decreased significantly. This study was aimed to elucidate the chemical characteristics of Paris fargesii var. brevipetala (PFB) that may be administrated as alternate resource of legal RP. A HPLC-ELSD m...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2012.01.003
更新日期:2012-06-01 00:00:00
abstract::Five new carboxymethyl flavonoids named 5-carboxymethyl-3', 4', 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3', 4', 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3', 4', 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4', 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4', 7-dihydroxyflavone (4), and a new chro...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2016.04.022
更新日期:2016-06-01 00:00:00
abstract::The effect of basil oil on the phagocytic capability and respiratory burst response of mouse peritoneal macrophages was studied. The oil inhibited the phagocytosis of opsonized sheep erythrocytes. This inhibition was both dose- and time-dependent and reverted 24 h after removing the extract from the culture medium. On...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(02)00117-x
更新日期:2002-08-01 00:00:00
abstract::Hepatitis C virus (HCV) infection is highly prevalent among global populations, with an estimated number of infected patients being 170 million. Approximately 70-80% of patients acutely infected with HCV will progress to chronic liver disease, such as liver cirrhosis and hepatocellular carcinoma, which is a substantia...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2014.10.011
更新日期:2014-12-01 00:00:00
abstract::Acteoside, which belongs to the family of phenylethanoid glycosides (PhGs), has extensive biological activities, including strong antioxidant, anti-inflammatory, hepatoprotect, and cell apoptosis regulation. Like other PhGs compounds, the fate of acteoside in the gut for both parent polyphenols and their degradation p...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2016.05.004
更新日期:2016-07-01 00:00:00
abstract::Four new terpenoids, nemoralisins D-G (1-4), were isolated from the leaves and stems of Aphanamixis grandifolia, along with two known diterpenoids, nemoralisin C and nemoralisin. Among them, compound 1 is the first example of norsesquiterpenoid with δ-lactone moiety, and nemoralisins E-G (2-4), are a class of acyclic ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2013.10.014
更新日期:2014-01-01 00:00:00
abstract::The aqueous root extract of Mimosa pudica dose dependently inhibited the hyaluronidase and protease activities of Indian snakes (Naja naja, Vipera russelii and Echis carinatus) venom. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2004.01.006
更新日期:2004-06-01 00:00:00
abstract::Four new dihydrophenanthrenofuran, bleochranols A-D (1-4), along with 21 known compounds including phenanthrenes (5-14) and bibenzyls (15-25) were isolated and elucidated from the rhizomes of Bletilla ochracea. Combination of 1D/2D NMR techniques and the Electronic Circular Dichroism (ECD) spectroscopy based on the em...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2018.02.007
更新日期:2018-06-01 00:00:00
abstract::A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to identify and quantify the camptothecin quaternary derivative CPT8 for application in pharmacokinetics and tissue distribution studies. Rat plasma and tissue samples were extracted with methanol by using camptothecin as the internal sta...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2013.06.012
更新日期:2013-10-01 00:00:00
abstract::A stimulatory effect of apigenin-6-C-β-fucopyranoside (1) on glucose uptake was observed when rat soleus muscle was incubated with 1, 10 and 100 μM of this flavonoid glycoside. The presence of specific insulin signaling inhibitors, such as wortmannin, an inhibitor of phosphoinositide 3-kinase (PI3K), RO318220, an inhi...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2012.07.003
更新日期:2012-10-01 00:00:00
abstract::Chiratone (1), a rare new chiratane type triterpenoid, together with five known triterpenoids were isolated from the rhizomes of Drynaria fortunei (Kunze) J. Sm. The structure was characterized as 20β-hydroxychiratan-22-one on the basis of extensive 1D and 2D NMR, and MS spectroscopic analyses, and was further confirm...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2010.06.013
更新日期:2010-12-01 00:00:00
abstract::Two new isocoumarins (1 and 2), a new alkaloid (3), and a known N-acetyldopamine dimer (4) were isolated from the ethyl acetate extract of Chinese insect medicine Eupolyphaga sinensis. Their structures were elucidated on the basis of detailed spectroscopic investigations, such as 1D- and 2D NMR spectroscopy, as well a...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2012.06.005
更新日期:2012-10-01 00:00:00
abstract::A new C(18)-phytosphingosine ceramide containing non-hydroxy fatty acid, armillaramide (1), has been isolated together with ergosterol peroxide from the fruiting bodies of the basidiomycete Armillaria mellea. Its structure was established as (2S,3S,4R)-2-hexadecanoylamino-octadecane-1,3,4-triol by spectroscopic and ch...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(01)00319-7
更新日期:2001-12-01 00:00:00
abstract::The effect of berberine hydrochloride (BBR) on inducible cyclooxygenase-2 (COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia. The results showed that lipopolysaccharide (LPS) increased COX-2 expression, whereas SB202190 and BBR curtailed it. LPS increased pho...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2011.05.013
更新日期:2011-10-01 00:00:00
abstract::Imperatorin (Imp) as a hypotensive active ingredient, its hypotensive effect was evaluated in the SHRs, its calcium antagonism and affinity to L-type calcium channel was also confirmed. The results showed that the blood pressure was decreased in the SHRs treated with Imp, the aortic ring was relaxed with Imp, L-type c...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2011.05.016
更新日期:2011-10-01 00:00:00
abstract::A fast and efficient method for the isolation of the C-glucosidated xanthones mangiferin and isomangiferin from the South-African plant Cyclopia genistoides was developed for the first time. The procedure involved extraction, liquid-liquid partitioning with ethyl acetate and subsequent precipitation of mangiferin and ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2013.07.020
更新日期:2013-10-01 00:00:00
abstract::Five new steroids, colebrin A-E (1-5) were isolated from the aerial parts of Clerodendrum colebrookianum. The structures of the new compounds were elucidated on the basis of spectral evidence. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(00)00223-9
更新日期:2000-12-01 00:00:00
abstract::Phytochemical study on rhizomes of Cimicifuga dahurica resulted in the isolation of nine new neolignan and phenylpropanoid glycosides, cimicifugasides A-E (1, 2, 7-9), cimicifugamides B-D (3-5), shomaside G (6) along with four known compounds (10-13). Their structures were identified by extensive spectroscopic analyse...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2019.03.023
更新日期:2019-04-01 00:00:00
abstract::Lanaroflavone (1), a biflavonoid isolated from the methanol extract of the aerial part of Campnosperma panamense by bioguided fractionation, has been assessed for in vitro antiprotozoal activity. Lanaroflavone showed both antimalarial and leishmanicidal activities, but was inactive against Chagas disease vector, Trypa...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2004.09.015
更新日期:2004-12-01 00:00:00
abstract::Five novel globoscinic acid derivatives, aspergilates A-E (1-5) have been isolated from endophytic fungus Aspergillus sp. derived from Paeonia ostii. The structures of aspergilates A-E were determined by in-depth analyses of NMR spectra, HRESIMS and CD experiments. The absolute configurations of compounds 2-5 were det...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2018.10.027
更新日期:2018-11-01 00:00:00
abstract::The essential oil from the aerial parts of Seseli annuum, wild-growing in Serbia, was obtained by hydrodistillation and analyzed using GC and GC/MS. A total of 43 components were identified representing 96.5% of S. annuum oil. The most abundant compounds were germacrene D (29.8%), sabinene (10.3%), beta-ocimene Z (9.8...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2007.03.014
更新日期:2007-06-01 00:00:00
abstract::The first chemical examination of roots of the traditionally used medicinal plant Talinum triangulare (Portulacaceae) from Nigeria led to the isolation of two new C-methylated flavonoids, 5,6-dimethoxy-7-hydroxy-8-methyl-flavone (1), 5,6-dimethoxy-8-methyl-2-phenyl-7H-1-benzopyran-7-one (2), and one new α-pyrone deriv...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2016.01.002
更新日期:2016-03-01 00:00:00
abstract::Dragon's blood is a rare and precious traditional medicine used by different cultures since ancient times. However, studies on enhancing the rapid accumulation of dragon's blood in Dracaena cambodiana and determining its formation mechanism are unavailable. In this study, the activities of two fungi, namely, BJDC01 an...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2013.03.012
更新日期:2013-06-01 00:00:00
abstract::Two novel 2-arylbenzofuran dimers, shandougenines A (1) and B (2), and two new polyisoprenylated flavanones 3 (shandougenine C) and 4 (shandougenine D) were isolated from the 95% EtOH extract of Sophora tonkinensis, together with 18 known compounds. Their structures were determined on the basis of spectral data interp...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2014.08.019
更新日期:2014-12-01 00:00:00
abstract::Phytochemical studies on the ethanol extract of the aerial parts of Ecdysanthera rosea led to the isolation of three new compounds, hydroquinone diglycoside acyl esters, ecdysanrosin A (1) and sesquiterpene, 5β-hydroperoxycostic acid (2) and apocarotenoid, 2, 4, 7-trimethyl-2, 4, 6, 8-tetraene-dialdehyde (3). Their st...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2010.06.001
更新日期:2010-10-01 00:00:00
abstract::A new cyclopeptide, pulvpeptin A (1), two pairs of norlignan lignanosides, tamariscinosides G and H (2, 3), together with five known compounds (4-8) were isolated from Selaginella pulvinata. The structures were elucidated by spectroscopic data and chemical degradation. The activity of tamariscinoside G (2) was evaluat...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2020.104562
更新日期:2020-06-01 00:00:00