Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia.

Abstract:

:The effect of berberine hydrochloride (BBR) on inducible cyclooxygenase-2 (COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia. The results showed that lipopolysaccharide (LPS) increased COX-2 expression, whereas SB202190 and BBR curtailed it. LPS increased phosphorylation of mucosal p38 MAPK and ATF2 as well as production of ATF2, whereas BBR attenuated these effects. LPS upregulated mucosal peroxisome proliferator-activated receptor gamma (PPARγ), but BBR reduced this receptor. GW9662 aggravated LPS-induced and reversed BBR-attenuated COX-2 expression. The findings showed that BBR ameliorated COX-2 overexpression partially via modulation of p38 and PPARγ pathways during acute endotoxemia.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Feng AW,Yu C,Mao Q,Li N,Li QR,Li JS

doi

10.1016/j.fitote.2011.05.013

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

976-82

issue

7

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(11)00142-0

journal_volume

82

pub_type

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