Abstract:
:The effect of berberine hydrochloride (BBR) on inducible cyclooxygenase-2 (COX-2) in small intestinal mucosa and related mechanisms was investigated in a rat model of acute endotoxemia. The results showed that lipopolysaccharide (LPS) increased COX-2 expression, whereas SB202190 and BBR curtailed it. LPS increased phosphorylation of mucosal p38 MAPK and ATF2 as well as production of ATF2, whereas BBR attenuated these effects. LPS upregulated mucosal peroxisome proliferator-activated receptor gamma (PPARγ), but BBR reduced this receptor. GW9662 aggravated LPS-induced and reversed BBR-attenuated COX-2 expression. The findings showed that BBR ameliorated COX-2 overexpression partially via modulation of p38 and PPARγ pathways during acute endotoxemia.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Feng AW,Yu C,Mao Q,Li N,Li QR,Li JSdoi
10.1016/j.fitote.2011.05.013subject
Has Abstractpub_date
2011-10-01 00:00:00pages
976-82issue
7eissn
0367-326Xissn
1873-6971pii
S0367-326X(11)00142-0journal_volume
82pub_type
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