Prenylated 4-phenylcoumarins and 4-alkylcoumarins from Kielmeyera argentea and their cytotoxic activity.

abstract：:One new Euphane-type triterpenoid 3β-hydroxytirucalla-5, 24-dien-21-oic acid (1), and ten known compounds (2-11) were isolated from Melia azedarach L. through bioassay-guided chemical analysis. The structures of the isolated compounds were established by means of 1D and 2D NMR spectroscopic ((1)H, (13)C, DEPT, COSY, H...

journal_title：Fitoterapia

authors： Khan MF,Rawat AK,Pawar B,Gautam S,Srivastava AK,Negi DS

更新日期：2014-10-01 00:00:00

abstract：:The Src-homology 2 domain-containing phosphatase 2 (SHP2), encoded by PTPN11, has been reported oncogenic tyrosine phosphatase associated with various tumors and played critical roles in many cell signaling events. Targeting SHP2 by small molecules may be a promising way for cancer therapy. Herein, a new abietane dite...

journal_title：Fitoterapia

authors： Liu DM,Cao ZX,Yan HL,Li W,Yang F,Zhao WJ,Diao QC,Tan YZ

更新日期：2020-03-01 00:00:00

abstract：:A new sesquiterpene lactone, 7alpha,10alpha-epoxy-1alpha(H),5alpha(H)-guaia-3,11(13)-dien-8alpha,12-olide, was isolated from the leaves of Hedyosmum arborescens. The structure of this unusual 7,10-epoxy-guaianolide was determined by spectroscopic methods, particularly one- and two-dimensional 1H and 13C NMR. ...

journal_title：Fitoterapia

authors： Bercion S,Couppe de K Martin MA,Baltaze JP,Bourgeois P

更新日期：2005-12-01 00:00:00

abstract：:6,7-Dimethylesculetin (D), geniposide (G) and rhein (R) are the three major active ingredients of Yin-Chen-Hao-Tang (YCHT), a famous Chinese herbal formula, which has been shown to be clinically effective for treating hepatic injury (HI) syndrome. The present study was conducted to investigate the therapeutic and syne...

journal_title：Fitoterapia

authors： Zhang A,Sun H,Yuan Y,Sun W,Jiao G,Wang X

更新日期：2011-12-01 00:00:00

abstract：:To determine whether the two major compounds of Erythrina lysistemon are active principles accounting for Erythrina estrogenic effects, we used a postmenopause-like model of ovariectomized Wistar rats to evaluate their effects on some menopausal problems. Ovariectomized rats were orally treated either with compound 1 ...

journal_title：Fitoterapia

authors： Mvondo MA,Njamen D,Fomum ST,Wandji J,Vollmer G

更新日期：2011-10-01 00:00:00

abstract：:Linarin (acacetin-7-O-beta-d-rutinoside) from the flower extract of Mentha arvensis showed selective dose dependent inhibitory effect on acetylcholinesterase. ...

journal_title：Fitoterapia

authors： Oinonen PP,Jokela JK,Hatakka AI,Vuorela PM

更新日期：2006-09-01 00:00:00

abstract：:Four pairs of racemic phenylpropanoids (1a/1b-4a/4b), including five new compounds (1a/1b, 2a, 3a, and 4a) were obtained from the root barks of Ailanthus altissima (Mill.) Swingle. Their structures were determined by comprehensive spectroscopic analyses. The absolute configurations of the enantiomers were determined b...

journal_title：Fitoterapia

authors： Yan ZY,Chen JJ,Duan ZK,Yao GD,Lin B,Wang XB,Huang XX,Song SJ

更新日期：2018-10-01 00:00:00

abstract：:The ecological role of maytansine, an important antineoplastic and antimicrobial compound with high cytotoxicity, particularly as a chemical defense compound has remained elusive since its discovery in the 1970s in Maytenus and Putterlickia plants. In the present study, we have used MALDI-imaging-HRMS to visualize the...

journal_title：Fitoterapia

authors： Eckelmann D,Kusari S,Spiteller M

更新日期：2017-06-01 00:00:00

abstract：:The present study investigates the effect of in vivo administration of alcoholic extract of Tinospora cordifolia whole plant (ALTC) on the proliferation and myeloid differentiation of bone marrow hematopoietic precursor cells in mice bearing a transplantable T cell lymphoma of spontaneous origin designated as Dalton's...

journal_title：Fitoterapia

authors： Singh SM,Singh N,Shrivastava P

更新日期：2006-01-01 00:00:00

abstract：:Cyclotides describe a unique cyclic peptide family that displays a broad range of biological activities including uterotonic, anti-bacteria, anti-cancer and anti-HIV. The vigno cyclotides consist of vigno 1-10 were reported recently from Viola ignobilis. In the present study, we examined the effects of vigno 5, a natu...

journal_title：Fitoterapia

authors： Esmaeili MA,Abagheri-Mahabadi N,Hashempour H,Farhadpour M,Gruber CW,Ghassempour A

更新日期：2016-03-01 00:00:00

abstract：:Solanum nigrum L. (also called as European black nightshade) has been traditionally used as folk medicine and food in some regions. Phytochemical investigations of the immature fruits of S. nigrum yielded five steroidal alkaloid glycosides (1-5), including an unprecedented nor-spirosolane type steroidal alkaloid with ...

journal_title：Fitoterapia

authors： Xiang L,Wang Y,Yi X,He X

更新日期：2019-09-01 00:00:00

abstract：:A chemical investigation of the 80% EtOH extract of the aerial plant of Alstonia rupestris afforded four new monoterpenoid indole alkaloids, 6,7-epoxy-8-oxo-vincadifformine (1), 11-acetyl-6,7-epoxy-8-oxo-vincadifformine (2), 11-hydroxy-14-chloro-15-hydroxy-vincadifformine (3), and perakine N1,N4-dioxide (4), together ...

journal_title：Fitoterapia

authors： Zhang L,Hua Z,Song Y,Feng C

更新日期：2014-09-01 00:00:00

abstract：:A different type of biologically active compound from Kuji amber (Late Cretaceous, Japan) before the K-Pg boundary [65 million years ago (Ma)] was isolated based on the growth-restoring activity of a mutant yeast involving Ca2+ signal transduction. It was identified as a spirolactone norditerpenoid, (4R*, 5S*, 8R*, 9R...

journal_title：Fitoterapia

authors： Shimizu E,Koshino H,Noro A,Maruyama M,Shimoda N,Uesugi S,Ohnishi M,Kimura KI

更新日期：2019-04-01 00:00:00

abstract：:Phytochemical study on rhizomes of Beesia calthifolia resulted in the isolation of five new (1-5) and three known (6-8) cycloartane triterpenoids possessing a hemiketal or ketal group at C-24 from the EtOAc fraction of 95% ethanol extract. Their structures were determined by spectroscopic and chemical methods, especia...

journal_title：Fitoterapia

authors： Zheng DJ,Zhou J,Liu Q,Yao W,Zhang MZ,Shao BH,Mo JX,Zhou CX,Gan LS

更新日期：2015-06-01 00:00:00

abstract：:The alkaloidal fraction obtained from an ethanolic extract of the leaves of Mikania cordata exhibited significant in vivo antiulcer activity in diclofenac sodium-induced gastric erosions in Long Evans rats. ...

journal_title：Fitoterapia

authors： Paul RK,Jabbar A,Rashid MA

更新日期：2000-12-01 00:00:00

abstract：:The leaf essential oil of Filipendula vulgaris, consisting mainly of salicylaldehyde (68.6%), was screened for its antimicrobial activity by the disk diffusion and microdilution broth assays. The essential oil remarkably inhibited the growth of all of the tested bacteria and fungi. It seems that the antimicrobial natu...

journal_title：Fitoterapia

authors： Radulović N,Misić M,Aleksić J,Doković D,Palić R,Stojanović G

更新日期：2007-12-01 00:00:00

abstract：:Rats treated with 100 mg /kg/day of the Catharanthus roseus ethanol extract had high rate of wound contraction significantly decreased epithelization period, significant increase in dry weight and hydroxyproline content of the granulation tissue when compared with the controls. Wound contraction together with increase...

journal_title：Fitoterapia

authors： Nayak BS,Anderson M,Pinto Pereira LM

更新日期：2007-12-01 00:00:00

abstract：:The ethanolic extract of Lawsonia inermis leaves and lawsone tested for trypsin inhibitory activity showed an IC(50) value of 64.87 and 48.6 microg/ml, respectively. ...

journal_title：Fitoterapia

authors： Yogisha S,Samiulla DS,Prashanth D,Padmaja R,Amit A

更新日期：2002-12-01 00:00:00

abstract：:Five pyrrolizidine alkaloids have been isolated from Heliotropium subulatum and tested for their antimicrobial activity. ...

journal_title：Fitoterapia

authors： Singh B,Sahu PM,Singh S

更新日期：2002-04-01 00:00:00

abstract：:Rapid micropropagation of Nepeta rtanjensis, N. sibirica and N. nervosa was performed. Qualitative and quantitative nepetalactone content in methanol extracts of in vitro grown plants was analysed by reverse-phase HPLC coupled with UV and MS detection. Only trans,cis-nepetalactone was detected in shoots of N. rtanjens...

journal_title：Fitoterapia

authors： Nestorović J,Misić D,Siler B,Soković M,Glamoclija J,Cirić A,Maksimović V,Grubisić D

更新日期：2010-09-01 00:00:00

abstract：:Fourteen pregnane-type steroidal alkaloids were isolated from the ethanolic extracts of whole Sarcococca hookeriana var. digyna plants. Their structures were elucidated on the basis of spectral data. Three of them were identified as new steroidal alkaloids: (S)-20-(N,N-dimethylamino)-16α,17α-epoxy-3β-methoxy-pregn-5-e...

journal_title：Fitoterapia

authors： Zhang PZ,Wang F,Yang LJ,Zhang GL

更新日期：2013-09-01 00:00:00

abstract：:The aqueous extract of Crinum giganteum given intraperitoneally at doses of 6.25, 12.5 and 25 mg/kg in rats prolonged the duration of pentobarbital sleeping time and in mice reduced spontaneous motor activity, decreased the exploratory activity and attenuated amphetamine-induced stereotype behavior. The intraperitonea...

journal_title：Fitoterapia

authors： Amos S,Binda L,Akah P,Wambebe C,Gamaniel K

更新日期：2003-02-01 00:00:00

abstract：:A weak estrogenicity of puerarin on reproductive organs was addressed in female rats. In short-term treatment, immature ovariectomized rats were injected with 0.7 mg/kg BW/day of puerarin, for 14 days. Puerarin did not increase uterus weights, endometrium and myometrium areas, and the percent of cornified cells (%Co),...

journal_title：Fitoterapia

authors： Malaivijitnond S,Tungmunnithum D,Gittarasanee S,Kawin K,Limjunyawong N

更新日期：2010-09-01 00:00:00

abstract：:A new altersolanol derivative, 4-dehydroxyaltersolanol A (9), along with two known sesquiterpenoids, (S)-7'-hydroxyabscisic acid (7) and (S)-abscisic acid (8) were obtained from the endophytic fungus, Nigrospora oryzae, isolated from leaves of Combretum dolichopetalum. The host plant yielded six known compounds includ...

journal_title：Fitoterapia

authors： Uzor PF,Ebrahim W,Osadebe PO,Nwodo JN,Okoye FB,Müller WE,Lin W,Liu Z,Proksch P

更新日期：2015-09-01 00:00:00

abstract：:Five rare dichloro aromatic polyketides (1-5) were obtained from an endophytic fungus Penicillium sp., along with five known metabolites (6-10). Their structures were elucidated by extensive spectroscopic analysis, Mosher methods, as well as [Rh2(OCOCF3)4]-induced electronic circular dichroism (ECD) experiments. Compo...

journal_title：Fitoterapia

authors： Yang MH,Li TX,Wang Y,Liu RH,Luo J,Kong LY

更新日期：2017-01-01 00:00:00

abstract：:Total sennosides concentration is a very important factor when rhubarb and senna will be used as crude drugs. However, one-step analytical technique for total sennosides has not been reported except HPLC. An enzyme-linked immunosorbent assay (ELISA) for total sennosides concentration by using the combination of anti-s...

journal_title：Fitoterapia

authors： Morinaga O,Uto T,Sakamoto S,Tanaka H,Shoyama Y

更新日期：2009-01-01 00:00:00

abstract：:Thirty four terpenoids, including two new cadinane-type sesquiterpenoids containing conjugated aromatic-ketone moieties, curcujinone A (1) and curcujinone B (2), were isolated from 95% ethanol extract of the root tubers of Curcuma wenyujin. Their structures were determined by spectroscopic methods, especially 2D NMR a...

journal_title：Fitoterapia

authors： Zhou CX,Zhang LS,Chen FF,Wu HS,Mo JX,Gan LS

更新日期：2017-09-01 00:00:00

abstract：:Five vibralactone derivatives containing γ, δ, ε-lactone cores, namely vibralactones X (1), Y (2), and Z1-Z3 (3-5), together with the known vibralactone, have been isolated from cultures of the basidiomycete Boreostereum vibrans. Compounds 3-5 possessed a novel bis-γ-lactone group which was found in vibralactone deriv...

journal_title：Fitoterapia

authors： Duan KT,Li ZH,Yu X,Yuan QX,Wang WX,Li J,Chen HP,Feng T,Liu JK

更新日期：2018-07-01 00:00:00

abstract：:Seven new lignans, cleistonkinins A- E (1-5), cleistonkisides A and B (6-7) were isolated from the fruits of Cleistanthus tonkinensis (Euphorbiaceae), together with five known aryltetralin lignans, cleisindoside B (8), cleistantoxin (9), cleisindoside D (10), neocleistantoxin (11) and polygamain (12). Their structures...

journal_title：Fitoterapia

authors： Nguyen LH,Vu VN,Phi Thi D,Tran VH,Litaudon M,Roussi F,Nguyen VH,Chau VM,Doan Thi Mai H,Pham VC

更新日期：2020-01-01 00:00:00

abstract：:Two new alkaloids were isolated from the bark of Sarcomelicope megistophylla. Cyclomegistine B (1), a new quinolone alkaloid, that possesses a rare cyclobuta[b]quinoline ring system and sarcomejine B (2) which is a quinolone alkaloid with an unusual side chain. The structure of both compounds was elucidated on the bas...

journal_title：Fitoterapia

authors： Mitaku S,Fokialakis N,Magiatis P,Tillequin F

更新日期：2007-02-01 00:00:00