Abstract：
:Cyclotides describe a unique cyclic peptide family that displays a broad range of biological activities including uterotonic, anti-bacteria, anti-cancer and anti-HIV. The vigno cyclotides consist of vigno 1-10 were reported recently from Viola ignobilis. In the present study, we examined the effects of vigno 5, a natural cyclopeptide from V. ignobilis, on cervical cancer cells and the underlying mechanisms. We found that vigno 5-treated Hela cells were killed off by apoptosis in a dose-dependent manner within 24h, and were characterized by the appearance of nuclear shrinkage, cleavage of poly (ADP-ribose) polymerase (PARP) and DNA fragmentation. The mitochondrial pathway of apoptosis revealed that cytochrome C is released from mitochondria to cytosol, associated with the activation of caspase-9 and -3, and the cleavage of poly (ADP-ribose) polymerase (PARP). Overall, the results indicate that vigno 5 induces apoptosis in part via the mitochondrial pathway, which is associated with a release of cytochrome C and elevated activity of caspase-9 and -3 in Hela cells.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Esmaeili MA,Abagheri-Mahabadi N,Hashempour H,Farhadpour M,Gruber CW,Ghassempour Adoi
10.1016/j.fitote.2015.12.021subject
Has Abstractpub_date
2016-03-01 00:00:00pages
162-8eissn
0367-326Xissn
1873-6971pii
S0367-326X(15)30151-9journal_volume
109pub_type
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