Abstract：
:Salvianolic acid B (Sal B) is the most abundant phenolic compound in Salvia miltiorrhiza, which has been widely used for the treatment of cardiovascular diseases in Oriental medicine. To elucidate structure of the converted compounds of Sal B by decoction in aqueous solution, Sal B (200 mg) was decocted in an aqueous solution (200 mL) at pH 4.9 and the decocted solution was purified by Sephadex LH-20 column chromatography and preparative HPLC. The 13 converted compounds were isolated and the chemical structures were determined by NMR and MS. In addition to the 4 compounds previously reported as conversion products of Sal B by decoction, 9 compounds were first reported with the complete structure of compounds isolated from decocted Sal B solution and three of the compounds were determined to be novel compounds. In addition, a conversion mechanism of compounds converted by decoction was proposed on the basis of kinetics studies, which reasonably supported the conversion mechanism of Sal B. The 13 compounds seemed to be produced by the hydrolysis of an ester bond, decarboxylation, retro oxa-Michael reaction, hydration, and radical reaction during decoction in aqueous solution.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Lee HJ,Cho JY,Moon JHdoi
10.1016/j.fitote.2012.06.015subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1196-204issue
7eissn
0367-326Xissn
1873-6971pii
S0367-326X(12)00183-9journal_volume
83pub_type
杂志文章相关文献
FITOTERAPIA文献大全abstract：:Claims that Traditional/Alternative medicine (TM/AM) remedies are effective are routinely ignored by Western Medicine. However, the results of a clinical trial that demonstrated the clinical efficacy of Tripterygium wilfordii Hook F. (TW), a TM used as an anti-inflammatory, were recently published in the Annals of Int...
journal_title：Fitoterapia
pub_type： 杂志文章,评审
doi：10.1016/j.fitote.2010.11.024
更新日期：2011-01-01 00:00:00
abstract：:To determine whether the two major compounds of Erythrina lysistemon are active principles accounting for Erythrina estrogenic effects, we used a postmenopause-like model of ovariectomized Wistar rats to evaluate their effects on some menopausal problems. Ovariectomized rats were orally treated either with compound 1 ...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2011.05.009
更新日期：2011-10-01 00:00:00
abstract：:Aconitum carmichaelii has been used in traditional Chinese medicine for treating various diseases for several thousand years. Based on the biosynthetic pathway of some alkaloids such as C19-diterpenoid alkaloids and obvious differences in alkaloid content between leaves of two A. carmichaelii varieties has been report...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2019.104412
更新日期：2020-01-01 00:00:00
abstract：:Escin exerts potent glucocorticoid-like anti-inflammatory effects. The aim of this study was to investigate whether the anti-inflammatory effect of escin is through the up-regulation of glucocorticoids and if escin induces pathological changes in immune organs. Mice were administrated with escin intravenously for 7 da...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2011.04.004
更新日期：2011-09-01 00:00:00
abstract：:The aqueous extract of Crinum giganteum given intraperitoneally at doses of 6.25, 12.5 and 25 mg/kg in rats prolonged the duration of pentobarbital sleeping time and in mice reduced spontaneous motor activity, decreased the exploratory activity and attenuated amphetamine-induced stereotype behavior. The intraperitonea...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/s0367-326x(02)00287-3
更新日期：2003-02-01 00:00:00
abstract：:A new diterpenoid ester, fritillahupehin (1) together with three known fatty acids: palmitic acid (2), lignoceric acid (3) and azelaic acid (4) were isolated from the bulbs of Fritillaria hupehensis Hsiao and K.C. Hsia. The structure of fritillahupehin has been established to be ent-kauran-16beta-yl lignocerate by mea...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/s0367-326x(02)00085-0
更新日期：2002-07-01 00:00:00
abstract：:Picrasamide A (1), a new cinnamamide derivative, together with two new β-carboline alkaloids (2 and 3) and five known β-carboline alkaloids (4-8) were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were elucidated by detailed analyses of UV, IR, HRESIMS, and NMR data. Compound 1 was th...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2019.104375
更新日期：2019-11-01 00:00:00
abstract：:Five new megastigmane glycosides, urenalobasides A-E (1-5), together with 11 known ones (6-16) were isolated from Urena lobata. Their structures were determined by extensive spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism method. Compounds 1 and 2 are ...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2018.02.017
更新日期：2018-06-01 00:00:00
abstract：:Investigation of the dichloromethane extract of the stem of Filicium decipiens yielded a new natural product, 24-norneohopa-4(23),22(29)-diene-3beta,6beta,7beta-triol 7-caffeate (1). ...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/s0367-326x(01)00296-9
更新日期：2001-11-01 00:00:00
abstract：:Illicium verum is a well known spice in traditional Indian system for its therapeutic potential. The present study was aimed to evaluate the acetylcholinesterase (AChE) and butyrylcholinesterase inhibitory (BChE) activity of standardized extracts of I. verum and its oil. Present study confirmed that anethole contribut...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2010.11.003
更新日期：2011-04-01 00:00:00
abstract：:Ten new highly oxygenated lanostane triterpenoids, stereinones A-J (1-10), were isolated from the fruiting bodies of the basidiomycete Stereum sp. Compounds 3 and 4 are structurally characterized as intact lanostane-type triterpenoids containing unusual 1,2-diketone functionality at C-11 and C-12, while compound 10 is...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2017.11.020
更新日期：2018-03-01 00:00:00
abstract：:Investigation of the bioactive secondary metabolites of the marine actinomycetes Rubrobacter radiotolerans led to the isolation and characterization of two naturally rare dimeric indole derivatives (1 and 2). The structures of these new compounds were elucidated by spectroscopic data interpretation, and the absolute c...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2015.01.014
更新日期：2015-04-01 00:00:00
abstract：:An ethnobotanical and ethnopharmacognostic survey has been carried out in one of the most isolated mountainous area in Europe: the village of Lepushe and its surrounding territory, in the Northern Albanian Alps. Approximately 70 botanical taxa and 160 preparations, mainly derived from plants, but also derived from ani...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2005.03.015
更新日期：2005-06-01 00:00:00
abstract：:Influenza poses a particular risk of severe outcomes in the elderly, the very young and those with underlying diseases. Tea polyphenols are the natural phenolic compounds in teas, and principally consist of catechins, proanthocyanidins, flavonols, and theaflavins, which antiviral activities have been reported recently...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2013.12.011
更新日期：2014-03-01 00:00:00
abstract：:Five new phthalides (1-4, 6), two new natural products (5, 7) and five known phthalides (8-12) were isolated from the aerial parts of Ligusticum sinense Oliv cv. Chaxiong. Their structures were elucidated by HR-ESI-MS, UV, IR, 1D and 2D NMR (HSQC, HMBC, (1)H-(1)H COSY, NOESY) methods. The absolute configurations were ...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2014.01.010
更新日期：2014-03-01 00:00:00
abstract：:The secondary metabolite pattern of Eryngium tricuspidatum has been found to be dominated by C17 acetylene oxylipins, according to the chemistry reported in the literature for the genus Eryngium. Two new oxylipins, 11-acetoxy-falcarindiol (4) and 1,2-dihydro-11-acetoxy-falcarindiol (5) have been isolated, along with m...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2019.104355
更新日期：2019-10-01 00:00:00
abstract：:Antioxidant activity of the ethanol extract of Erigeron breviscapus (EEEB) were studied by using neuron oxidative injury model induced by superoxide radical. EEEB at the dose of 10-140 mug/ml reduced significantly the lipid peroxidation levels and lactic dehydrogenase (LDH) release from neuron exposed to superoxide ra...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2005.08.014
更新日期：2005-12-01 00:00:00
abstract：:Four new lignanamides, melongenamides A-D (1-4), together with six known ones (5-10), were isolated from the roots of Solanum melongena L. Their structures were elucidated on the basis of 1D and 2D NMR experiments and by comparison of their spectroscopic and physical data with the literature values. Compounds 2-8 exhi...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2014.07.012
更新日期：2014-10-01 00:00:00
abstract：:Although the bioactive compounds in goji have been thoroughly identified and quantified, little information is available on the bitter compounds in the berries, and no systematic works on the substances responsible for their bitterness have been performed. Herein, the substances contributing to the bitterness of berri...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2020.104543
更新日期：2020-06-01 00:00:00
abstract：:Antimicrobial screening of Enantia polycarpa bark showed activity of the polar extracts against some microorganisms. ...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/s0367-326x(99)00153-7
更新日期：2000-06-01 00:00:00
abstract：:Eight new dihydrobenzofuran neolignans, pinnatifidanin C I-VIII (1-8), together with two known analogs (9-10) were isolated from the seeds of Crataegus pinnatifida. Their structures were elucidated by spectroscopic analyses, especially 1D, 2D NMR and CD spectra. The cytotoxic activities of all isolates against human c...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2013.09.011
更新日期：2013-12-01 00:00:00
abstract：:Goniothalamus macrophyllus (Blume) Hook. f. & Thoms. is a plant widely distributed in Malaysia. The aim of this study is to identify compounds from the roots of G. macrophyllus. The ground roots were extracted with aqueous methanol and partitioned sequentially with n-hexane, chloroform and butanol. Purification from t...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2013.03.028
更新日期：2013-07-01 00:00:00
abstract：:Traditional Indonesian medicinal plants were screened for their inhibitory effects on the nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and for the antioxidant activity through the evaluation of free radical scavenging effect and reducing power. The results of screening indic...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2004.11.010
更新日期：2005-03-01 00:00:00
abstract：:Ethanolic extract of Rungia repens aerials parts (300 and 600 mg/kg p.o) showed diuretic activity in rats. The acute toxicity, orally evaluated in mice, was found to be higher than 3000 mg/kg. ...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2005.11.007
更新日期：2006-02-01 00:00:00
abstract：:Reinvestigation of Onopordon ambiguum extract afforded a new eudesmane derivative 1, in addition to the known elemanoid derivative 2. The structures of both compounds were determined by spectroscopic techniques, including 1H-, 13C-NMR, DEPT, 1H-1H and 1H-13C COSY analysis. ...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/s0367-326x(01)00366-5
更新日期：2002-02-01 00:00:00
abstract：:A series of new Lycopodium alkaloids, namely 1-epi-malycorin A (1), 1-epi-17S-hydroxymalycorin A (2), 6α-hydroxyphlegmariurine A (3), 2S,4R-dihydroxyfawcettimine (4), and 16-hydroxylycodine (5), together with 24 known ones, have been isolated from the club moss Phlegmariurus henryi. The structures of the new compounds...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2016.10.005
更新日期：2016-12-01 00:00:00
abstract：:Two new depsidones, schomburgdepsidones A and B (1 and 2), and one new xanthone, schomburgxanthone A (3), together with eight known compounds (4-11) were isolated from the roots of Garcinia schomburgkiana. Their chemical structures were established on the basis of spectroscopic analysis. The in vitro cytotoxicity of a...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2016.04.012
更新日期：2016-06-01 00:00:00
abstract：:A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to identify and quantify the camptothecin quaternary derivative CPT8 for application in pharmacokinetics and tissue distribution studies. Rat plasma and tissue samples were extracted with methanol by using camptothecin as the internal sta...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2013.06.012
更新日期：2013-10-01 00:00:00
abstract：:Curcuminoids possess powerful antioxidant activity as demonstrated in many chemical in vitro tests and in several in vivo trials. Nevertheless, the mechanism of this activity is not completely elucidated and studies on the in vivo antioxidant effects are still needed. Metabolomics may be used as an attractive approach...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2015.12.013
更新日期：2016-03-01 00:00:00
abstract：:As part of our search for biologically active anti-osteoporotic agents that enhance the differentiation and mineralization of osteoblastic MC3T3-E1 cells, we identified the ginsenoside Rd as the most active compound among ginsenosides. In this study, we showed that Rd stimulates osteoblastic differentiation and minera...
journal_title：Fitoterapia
pub_type： 杂志文章
doi：10.1016/j.fitote.2011.10.017
更新日期：2012-01-01 00:00:00
