Abstract：
:One new Euphane-type triterpenoid 3β-hydroxytirucalla-5, 24-dien-21-oic acid (1), and ten known compounds (2-11) were isolated from Melia azedarach L. through bioassay-guided chemical analysis. The structures of the isolated compounds were established by means of 1D and 2D NMR spectroscopic ((1)H, (13)C, DEPT, COSY, HSQC and HMBC) and MS spectral analyses. All the fractions and isolated pure compounds were evaluated for antidiabetic activity by determining their inhibitory effects on PTP-1B enzyme as well as glucose uptake stimulation in C2Cl2 myoblasts cells. Compounds 4 and 7 showed significant in vitro PTP-1B inhibitory activity with 69.2 and 66.8% inhibition at 10 μg/ml concentrations respectively.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Khan MF,Rawat AK,Pawar B,Gautam S,Srivastava AK,Negi DSdoi
10.1016/j.fitote.2014.07.014subject
Has Abstractpub_date
2014-10-01 00:00:00pages
98-103eissn
0367-326Xissn
1873-6971pii
S0367-326X(14)00194-4journal_volume
98pub_type
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