Abstract:
:Diabetes is a worldwide healthy concern, which affects approximately 9% of the population. Tetrahydrocurcumin (THC) is the main metabolite of curcumin, which exerts the anti-diabetic activity. However, the underlying mechanism has not been clarified. In the research, we investigated whether THC could improve diabetes by regulating the gut microbiota and the expression of pancreatic glucagon-like peptide-1 (GLP-1) in the db/db mice. After 8-week THC administration (ig., once a day, THCH group: 200 mg/kg, THCL group: 100 mg/kg), the fasting blood glucose (FBG) was measured every two weeks. Serum insulin levels, the expression of GLP-1 in the pancreas, the histopathology of pancreas and the composition of gut microbiota were evaluated at the end of the experiment. Compared to the diabetic group, THC treatment decreased significantly blood glucose, increased the secretion of insulin and the expression of GLP-1 in the pancreas. Histomorphological analysis revealed that THC could protect pancreatic islet cells against hyperglycemic insult. Furthermore, the data from the sequencing of the 16S rDNA genes in gut microbiome displayed that THC could restore the intestinal dysbiosis, including the lowered relative abundance of Proteobacteria, Actinobacteria and the ratio of Firmicutes to Bacteroidetes. The linear regression analysis showed a close correlation between the GLP-1 expression and the proportion of the intestinal microflora. Altogether, these results demonstrated that THC might have a direct regulatory effect on gut microflora, which indirectly decrease the FBG levels by modulating GLP-1 expression in the pancreas.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Yuan T,Yin Z,Yan Z,Hao Q,Zeng J,Li L,Zhao Jdoi
10.1016/j.fitote.2020.104665subject
Has Abstractpub_date
2020-10-01 00:00:00pages
104665eissn
0367-326Xissn
1873-6971pii
S0367-326X(20)30247-1journal_volume
146pub_type
杂志文章相关文献
FITOTERAPIA文献大全abstract::To determine whether the two major compounds of Erythrina lysistemon are active principles accounting for Erythrina estrogenic effects, we used a postmenopause-like model of ovariectomized Wistar rats to evaluate their effects on some menopausal problems. Ovariectomized rats were orally treated either with compound 1 ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2011.05.009
更新日期:2011-10-01 00:00:00
abstract::Chemical investigation of the liquid culture of the endophytic fungus Bipolaris sorokiniana A606, which was isolated from the medicinal plant Pogostemon cablin resulted in the isolation of four new cytotoxic compounds, named isocochlioquinones D-E (1-2) and cochlioquinones G-H (3-4), along with five known cochlioquino...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2016.02.005
更新日期:2016-04-01 00:00:00
abstract::Five new cytochalasans (1-5) were isolated from the rice fermentation of fungus Xylaria longipes, along with seven known compounds cytochalasin P (6), cytochalasin D (7), zygosporin D (8), 7-O-acetylcytochalasin D (9), cytochalasin C (10), 6,7-dihydro-7-oxo-cytochalasin C (11), and 6,7-dihydro-7-oxo-deacetylcytochalas...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2019.104278
更新日期:2019-09-01 00:00:00
abstract::A new arylnaphthalene lignan, named furfuracin, was isolated from the leaves of Knema furfuracea (Myristicaceae), whereas 7 known compounds including (+)-trans-1,2-dihydrodehydroguaiaretic acid, fragransin A(2), biochanin A, gingkolic acid, anarcardic acid, 2-hydroxy-6-(12-phenyldodecyl)-benzoic acid and 2-hydroxy-6-(...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2009.05.005
更新日期:2009-09-01 00:00:00
abstract::The aerial parts of the endemic Australian plant Eremophila debilis (Myoporaceae) contain 3% dry weight of the biologically active 5,6,7,3',4',5'-hexamethoxyflavone, which had its structured confirmed using X-ray crystal crystallography. The presence of significant levels of the polypharmacologically active 5,6,7,3',4...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2017.07.014
更新日期:2018-04-01 00:00:00
abstract::Four new compounds, including three new steroids (1-3) and one new sesquiterpene (6), and two new natural products (4-5), as well as three known steroids (7-9) were isolated from the twigs of Turraea pubescens. Compounds 3-5 are C₂₂ steroids isolated from the Meliaceae family for the first time. Their structures were ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2013.07.006
更新日期:2013-10-01 00:00:00
abstract::Ten coumarins were isolated from Peucedanum luxurians. The rare coumarins stenocarpin, stenocarpin isobutyrate, officinalin, officinalin isobutyrate, 8-methoxypeucedanin and the known xanthotoxin, isoimperatorin, bergaptene, peucedanin and cnidilin were isolated. All isolated compound were identified by means of spect...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2007.04.004
更新日期:2007-09-01 00:00:00
abstract::The aqueous extract of the leaves of Musanga cecropioides did not affect ache-induced contractile response, but produced significant inhibition of the twitch and pendular movement of the rat and rabbit smooth muscles, respectively, and reduced writhing induced by acetic acid in mice. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(99)00130-6
更新日期:2000-04-01 00:00:00
abstract::Investigation of the bioactive secondary metabolites of the marine actinomycetes Rubrobacter radiotolerans led to the isolation and characterization of two naturally rare dimeric indole derivatives (1 and 2). The structures of these new compounds were elucidated by spectroscopic data interpretation, and the absolute c...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2015.01.014
更新日期:2015-04-01 00:00:00
abstract::Two new triterpenoid estersaponins (1, 2) were isolated from the leaves of Pittosporum tobira 'Variegata' (Thunb.) W. T. Aiton, along with one known saponin (3) and one known flavonoid glycoside (4). Their structures were established by different spectroscopic methods including 1D and 2D NMR, UV, as well as ESI-MS ana...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2015.09.006
更新日期:2015-10-01 00:00:00
abstract::The purpose of this investigation was to study the modulator and efflux pump inhibitor activity of coumarins isolated from Mesua ferrea against clinical strains as well as NorA-over expressed strain of Staphylococcus aureus 1199B. Seven coumarins were tested for modulator activity using ethidium bromide (EtBr) as a su...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2013.07.015
更新日期:2013-10-01 00:00:00
abstract::Five new benzylphenanthrenes, cremaphenanthrenes L-P (1-5) were isolated from the EtOAc-soluble extract of the tubers of Cremastra appendiculata. Their structures were elucidated based on the spectroscopic data and chemical methods. Compounds 1-5 were tested in vitro for their cytotoxic effects against colon (HCT-116)...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2015.03.003
更新日期:2015-06-01 00:00:00
abstract::Five rare dichloro aromatic polyketides (1-5) were obtained from an endophytic fungus Penicillium sp., along with five known metabolites (6-10). Their structures were elucidated by extensive spectroscopic analysis, Mosher methods, as well as [Rh2(OCOCF3)4]-induced electronic circular dichroism (ECD) experiments. Compo...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2016.11.008
更新日期:2017-01-01 00:00:00
abstract::Black carrot (Daucus carota L. ssp. sativus var. atrorubens Alef.) is a valuable source of carbohydrates, minerals and vitamins and contains also high amounts of anthocyanins giving the characteristic deep-purple color. These latter compounds are known as natural dyes used in the food and pharmaceutical industry that ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2017.10.006
更新日期:2018-01-01 00:00:00
abstract::As a part of our ongoing search for plant-derived compounds that inhibit nitric oxide production, the methanol extract of the roots of Vladimiria souliei was found to show significant inhibitory effects on INF-γ-induced nitric oxide production in murine macrophage RAW264.7 cells. Bioactivity-guided isolation of the ex...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2011.01.004
更新日期:2011-04-01 00:00:00
abstract::The tea seed triterpene saponin (TS) from Camellia sinensis was found to exhibit better antitumor activity in vivo in S180 implanted ICR mice and QR inducing activity for hepa lclc7 cells respectively compared with the total tea seed saponin (TTS), hydrolysate of the TTS and tea seed flavonoid glycosides (TF). By bioa...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2012.12.022
更新日期:2013-01-01 00:00:00
abstract::Cordia dichotoma f. (Boraginaceae) is a small deciduous tree from India. The bark of was used in the treatment of ulcerative colitis (UC) and colic pain traditionally hence present work was undertaken to identify the phytoconstituent responsible for this activity. Apigenin is isolated by column chromatography from met...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2011.06.008
更新日期:2011-10-01 00:00:00
abstract::Dichloromethane extract of propolis (DCME) originating from Pitcairn Island demonstrated potent cytotoxicity against triple-negative MDA-MB-231 human breast carcinoma cells. The results from MTT assay showed that DCME inhibits the growth of the cancer cells in a dose- and time-dependent manner and upon the cell growth...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2018.05.024
更新日期:2018-07-01 00:00:00
abstract::The estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum and five fractions obtained by solid-phase extraction were investigated using estrogen-responsive bioassays, a yeast cell assay and the Ishikawa Var-I assay. The extract was found to exhibit significant estrogenic activity in both...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2004.10.002
更新日期:2005-01-01 00:00:00
abstract::Six Patagonian plants were screened for proteolytic activity: Colliguaja integerrima, Euphorbia collina, E. peplus and Stillingia patagonica (Euphorbiaceae), Philibertia gilliesii (Asclepiadaceae) and Grindelia chiloensis (Asteraceae). P. gilliesii extracts showed the highest specific activity, followed by S. patagoni...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(03)00146-1
更新日期:2003-09-01 00:00:00
abstract::The ethanolic extracts of Lawsonia inermis leaves, Holarrhena antidysenterica bark, Swertia chirata whole plant and Mangifera indica bark were tested (in-vitro) for alpha-glucosidase inhibitory activity. M. indica extract was found to be the most potent, with an IC(50) value of 314 microg/ml. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(01)00293-3
更新日期:2001-08-01 00:00:00
abstract::Antimicrobial screening of Enantia polycarpa bark showed activity of the polar extracts against some microorganisms. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(99)00153-7
更新日期:2000-06-01 00:00:00
abstract::Two new xanthones: mangostanaxanthones I (3) and II (5) were isolated from the pericarp of Garcinia mangostana, along with four known xanthones: 9-hydroxycalabaxanthone (1), parvifolixanthone C (2), α-mangostin (4), and rubraxanthone (6). Their structures were elucidated on the basis of IR, UV, 1D, 2D NMR, and MS spec...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2014.08.014
更新日期:2014-10-01 00:00:00
abstract::Nagilactones are norditerpene dilactones isolated from the root bark of Podocarpus nagi. Although nagilactone E has been reported to show antifungal activities, its activity is weaker than that of antifungals on the market. Nagilactone E enhances the antifungal activity of phenylpropanoids such as anethole and isosafr...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2018.05.003
更新日期:2018-07-01 00:00:00
abstract::Crocetin (5-20 microg/ml), quercetin (10-40 microg/ml), and cisplatin (60-180 microg/ml) used as a positive control drug, were tested against human rhabdomyosarcoma (RD) cells and African green monkey kidney (Vero) cells. The cell viability, morphological changes, and lactate dehydrogenase activity were assessed. RD c...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(00)00138-6
更新日期:2000-08-01 00:00:00
abstract::A total of 58 fungal isolates, belonging to 24 genera, were obtained from the leaves, stems and roots of Ginkgo biloba L.. Among them, one endophytic fungal strain, Penicillium cataractum SYPF 7131, displayed the strongest antibacterial activity. Four new compounds (1-4) were isolated from the strain fermentation brot...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2018.05.033
更新日期:2018-07-01 00:00:00
abstract::The plants of genus Toona are well known for diverse limonoid secondary metabolites, while polyacetylenes are rarely found from Toona species. In this work, six new polyacetylenes toonasindiynes A-F (1-6) and six known analogues (7-12) were isolated from the root bark of Toona sinensis. Their structures and absolute c...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2020.104667
更新日期:2020-10-01 00:00:00
abstract::This manuscript reports on the first CE-method suitable for analyzing twelve pharmacologically relevant compounds (flavonoids, caffeic acids and leontopodic acid) in the aerial parts of Leontopodium alpinum. By using a 60mM borax buffer containing 25mM SDS and 35% acetonitrile the analytes could be well resolved in 25...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2012.09.023
更新日期:2012-12-01 00:00:00
abstract::A new triterpene glycoside (1) along with the known intercedenside B (2) was isolated from the sea cucumber Pseudocolochirus violaceus. Glycoside 1 was elucidated as 3-O-{6-O-sodiumsulfate-3-O-methyl-beta-D-glucopyranosyl-(1-->3)-beta-D-xylopyranosyl-(1-->4)-[beta-D-xylopyranosyl(1-->2)]-beta-D-quinovopyranosyl-(1-->2...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2007.02.010
更新日期:2007-06-01 00:00:00
abstract::The flavonoid fraction of Tephrosia purpurea (FFTP) was studied for its effect on cellular and humoral functions and on macrophage phagocytosis in mice. Oral administration of FFTP (10-40 mg/kg) significantly inhibited sheep red blood cells (SRBC)-induced delayed-type hypersensitivity reactions. It also produced a sig...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/s0367-326x(03)00042-x
更新日期:2003-04-01 00:00:00