Abstract：
:The gastrointestinal activity of hydroalcoholic extract (HE) of Salvia officinalis was evaluated in a model of ethanol-induced gastric lesion. HE showed excellent activity, with ID(50) 84.0 (54.8-128.9) mg/kg. The acetic acid-induced ulcer and the total acidity of the gastric secretion were also reduced by HE, and, in vitro experiments, the H(+),K(+)-ATPase activity was inhibited. Carnosol was identified as a possible active constituent for the gastroprotective effect of HE.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Mayer B,Baggio CH,Freitas CS,dos Santos AC,Twardowschy A,Horst H,Pizzolatti MG,Micke GA,Heller M,dos Santos EP,Otuki MF,Marques MCdoi
10.1016/j.fitote.2009.05.015subject
Has Abstractpub_date
2009-10-01 00:00:00pages
421-6issue
7eissn
0367-326Xissn
1873-6971pii
S0367-326X(09)00113-0journal_volume
80pub_type
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