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Schisandrin B co-treatment ameliorates the impairment on mitochondrial antioxidant status in various tissues of long-term ethanol treated rats.

Abstract：

:The effect of schisandrin B (Sch B) on long-term ethanol-induced oxidative stress in various rat tissues was investigated. Long-term ethanol treatment increased reactive oxygen metabolites (ROM) level in plasma. The ethanol-induced oxidative stress was assessed by mitochondrial glutathione and α-tocopherol levels, antioxidant enzyme activities, malondialdehyde (mtMDA) production and heat shock protein (Hsp) 25/70 levels. Liver was most susceptible to oxidative stress with a significant increase in mtMDA production. Long-term Sch B treatment enhanced mitochondrial antioxidant status in a tissue non-specific manner. Sch B co-treatment ameliorated the alterations in plasma ROM levels, mtMDA production and Hsp 25/70 expression in rat tissues.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Lam PY,Chiu PY,Leung HY,Chen N,Leong PK,Ko KM

doi

10.1016/j.fitote.2010.08.010

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1239-45

issue

8

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(10)00211-X

journal_volume

81

pub_type

杂志文章

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