Abstract:
:A phytochemical fractionation of the methanol extract of the Morus alba leaves led to the isolation of eleven flavonoids (1-11). The structure of the new 3'-geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone (1) was elucidated by means of spectroscopic methods. The cytotoxicity of the isolated compounds against human cervical carcinoma HeLa, human breast carcinoma MCF-7, and human hepatocarcinoma Hep3B cells was evaluated. Of note, morusin (9) was the most potent with an IC(50) value of 0.64 μM against HeLa cells.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Dat NT,Binh PT,Quynh le TP,Van Minh C,Huong HT,Lee JJdoi
10.1016/j.fitote.2010.08.006subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1224-7issue
8eissn
0367-326Xissn
1873-6971pii
S0367-326X(10)00207-8journal_volume
81pub_type
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