Abstract:
:Phytochemical investigation of methanolic extract of the whole plants of Vaccinium emarginatum allowed for the characterization of one epicatechin derivative (1) that was isolated from a natural source for the first time and three new flavonoids, emarginin A (2), emarginin B (3), and emarginin C (4), together with 11 known compounds (5-15). The structures of compounds 1-4 were elucidated by combination of spectroscopic analysis (MS, IR, and NMR) and by comparison with that of literature analogues. Compounds 1-8 and 11-15 were evaluated for their preliminary in vitro anti-proliferative activity against Du145 and PC-3 prostate cancer cell lines. Among them, compound 15 exhibited most potent cytotoxicity against Du145 and PC-3 cells, with IC50 values of 8.46 and 10.98 μM, respectively. Furthermore, compounds 1-7 were assessed for their anti-inflammatory potential against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells. Compound 4 exhibited moderate anti-inflammatory activity, with an IC50 value of 27.99 μM.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Tu PC,Liang YC,Huang GJ,Huang HC,Kao MC,Lu TL,Kuo YHdoi
10.1016/j.fitote.2019.104446subject
Has Abstractpub_date
2020-03-01 00:00:00pages
104446eissn
0367-326Xissn
1873-6971pii
S0367-326X(19)31609-0journal_volume
141pub_type
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