Lycocasuarines I-Q, new Lycopodium alkaloids isolated from Lycopodiastrum casuarinoides.

Abstract:

:Lycocasuarines I-Q (1-9), nine new lycodine-type Lycopodium alkaloids were isolated from the aerial parts of Lycopodiastrum casuarinoides (Spring) Holub ex R.D.Dixit. Their structures were unambiguously determined via extensive spectroscopic analyses, including HRESIMS, NMR, and electronic circular dichroism (ECD). The new alkaloids were evaluated for their in vitro inhibitory activity against acetylcholinesterase (AChE). Compounds 3, 5-8 exhibited marginal or weak activities with IC50 values ranging from 97.2 to 171.9 μM.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Zhu XL,Wang LL,Shi ZH,Xia D,Zhou ZB,Pan K

doi

10.1016/j.fitote.2019.03.027

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

474-480

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(19)30411-3

journal_volume

134

pub_type

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