Abstract:
:Five new limonoids, named sundarbanxylogranins A-E (1-5), were isolated from the seeds of an Indian mangrove, Xylocarpus granatum, collected from mangrove swamps of the Sundarbans, India. The structures of these limonoids were established by HRESIMS and NMR spectroscopic data. Sundarbanxylogranin A (1) is a rare limonoid containing a bicyclo[5.2.1]dec-3-en-8-one scaffold as the ring A/B-fused core; whereas sundarbanxylogranin B (2) is a typical mexicanolide with an 8α, 30α-epoxy ring. Sundarbanxylogranins C-E (3-5), among which the former two possess a 29-OMe group with different orientation, belong to a small group of limonoids containing a C1-O-C29 oxygen bridge. Sundarbanxylogranin B exhibited moderate anti-HIV activity with an IC50 value of 23.14±1.29μM and a CC50 value of 78.45±1.69μM, respectively.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Dai YG,Wu J,Padmakumar KP,Shen Ldoi
10.1016/j.fitote.2017.08.013subject
Has Abstractpub_date
2017-10-01 00:00:00pages
85-89eissn
0367-326Xissn
1873-6971pii
S0367-326X(17)31133-4journal_volume
122pub_type
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