当前位置： SCI文献检索 > FITOTERAPIA期刊下所有文献 > A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia.

A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia.

Abstract：

:The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivatives that are relatively selective ligands for the alpha7 nAChR. Flavonoids are not known for this activity, so we screened a small library of pure flavonoids to confirm our findings. Some flavonoids, e.g. rhamnetin, displaced a selective alpha7 nAChR radioligand from rat brain membranes whereas similar structures e.g. sakuranetin, did not. To evaluate the contribution of this putative nAChR activity to the known anti-inflammatory properties of these flavonoids, we compared their effects on lipopolysaccharide induced release of inflammatory mediators from BV2 microglia. Both rhamnetin and sakuranetin reduced mediator release, but differed in potency (rhamnetin>sakuranetin) and the Hill slope of their concentration-response curves. For rhamnetin the Hill coefficient was >3.0 whereas for sakuranetin the coefficient was 1.0, suggesting that effects of rhamnetin are mediated through more than one mechanism, whereas sakuranetin has a single mechanism. nAChR antagonists decreased the Hill coefficient for rhamnetin toward unity, which suggests that a nAChR-mediated mechanism contributes cooperatively to its overall anti-inflammatory effect. In contrast nAChR antagonists had no effect on the potency or Hill coefficient for sakuranetin, but a concentration of nicotine (1μM) that had no effect alone, significantly increased the Hill coefficient of this flavonoid. In conclusion, the anti-inflammatory effects of rhamnetin benefit cooperatively from a nAChR-mediated mechanism. This action, together with potent free radical scavenging activity, suggests that flavonoids with alpha7 nAChR activity have therapeutic potential in neuroinflammatory conditions.

journal_name

Fitoterapia

journal_title

Fitoterapia

authors

Lutz JA,Kulshrestha M,Rogers DT,Littleton JM

doi

10.1016/j.fitote.2014.06.012

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

11-21

eissn

0367-326X

issn

1873-6971

pii

S0367-326X(14)00176-2

journal_volume

98

pub_type

杂志文章

相关文献

FITOTERAPIA文献大全
  • Inhibitory effects of Zuo-Jin-Wan and its alkaloidal ingredients on activator protein 1, nuclear factor-κB, and cellular transformation in HepG2 cells.

    abstract：:Zuo-Jin-Wan (ZJW) has been used to treat hepatocellular carcinoma in Asia. This study was to determine whether ZJW and its components blocked activator protein 1 (AP-1) and nuclear factor-κB (NF-κB) activities as well as tumor promotion in hepatoblastoma HepG2 cells. ZJW and its components, Coptis chinensis and Evodia...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2011.02.009

    authors： Chao DC,Lin LJ,Kao ST,Huang HC,Chang CS,Liang JA,Wu SL,Hsiang CY,Ho TY

    更新日期：2011-06-01 00:00:00

  • Constituents of the trunk bark of Maquira coriacea.

    abstract：:The isolation of 14 known triterpenoids and phytosterols from the trunk bark of Maquira coriacea, and complete spectral data of a cardenolide, k-strophanthin-beta (1), are reported. ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/s0367-326x(01)00317-3

    authors： Mitaine-Offer AC,Sauvain M,Petermann C,Zèches-Hanrot M

    更新日期：2001-11-01 00:00:00

  • Four new quassinoids from the roots of Eurycoma longifolia Jack.

    abstract：:Seven compounds were isolated from the roots of Eurycoma longifolia, and characterized by comprehensive analysis of 1D and 2D NMR experiments along with single crystal X-ray diffraction. Among them, four new quassinoids were identified and three of them were diastereomers for each other. Compounds 1-7 were evaluated f...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2013.10.009

    authors： Meng D,Li X,Han L,Zhang L,An W,Li X

    更新日期：2014-01-01 00:00:00

  • Antifungal activity of Ajuga remota.

    abstract：:Successive petroleum ether, dichloromethane and methanol extracts of Ajuga remota aerial parts were tested in vitro for their antifungal activity. The petroleum ether fraction was found to be the most effective against the tested pathogens. ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/s0367-326x(00)00280-x

    authors： Kariba RM

    更新日期：2001-02-01 00:00:00

  • Megastigmane glycosides from Urena lobata.

    abstract：:Five new megastigmane glycosides, urenalobasides A-E (1-5), together with 11 known ones (6-16) were isolated from Urena lobata. Their structures were determined by extensive spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism method. Compounds 1 and 2 are ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2018.02.017

    authors： Su C,Qi B,Wang J,Ding N,Wu Y,Shi XP,Zhu ZX,Liu X,Wang XH,Zheng J,Tu PF,Shi SP

    更新日期：2018-06-01 00:00:00

  • Anti-proliferative and anti-neuroinflammatory eudesmanolides from Wedelia (Sphagneticola trilobata (L.) Pruski).

    abstract：:Wedelia (Sphagneticola trilobata, Syn. Wedelia trilobata), a notoriously invasive agricultural weed, can inhibit the growth and development of crops in the field. Eight new eudesmanolides (1-8), along with twelve known congeners (9-20), were isolated and identified from the flowers of Wedelia. Their chemical structure...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2019.104452

    authors： Sun L,Wang Z,Wang Y,Xu J,He X

    更新日期：2020-04-01 00:00:00

  • Antifungal activity of some Himalayan medicinal plants and cultivated ornamental species.

    abstract：:Extracts of roots of Rumex nepalensis, Berberis aristata, Arnebia benthamii, bark of Taxus wallichiana, Juglans regia and petals of Jacquinia ruscifolia were tested for their antifungal activity against twelve different fungal pathogens. Ethanolic extracts of R. nepalensis and J. ruscifolia extracts showed a broad spe...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2008.06.004

    authors： Sharma RS,Mishra V,Singh R,Seth N,Babu CR

    更新日期：2008-12-01 00:00:00

  • Antimicrobial activity of Securinega leucopyrus.

    abstract：:Extracts of the leaves of Securinega leucopyrus exhibited a broad spectrum of antimicrobial activity. ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/s0367-326x(01)00341-0

    authors： Bakshu LM,Jeevan Ram A,Venkata Raju R

    更新日期：2001-12-01 00:00:00

  • Pinostrobin from Cajanus cajan (L.) Millsp. inhibits sodium channel-activated depolarization of mouse brain synaptoneurosomes.

    abstract：:This investigation focuses on the in vitro neuroactive properties of pinostrobin, a substituted flavanone from Cajanus cajan (L.) Millsp. of the Fabaceae family. We demonstrate that pinostrobin inhibits voltage-gated sodium channels of mammalian brain (IC(50)=23 µM) based on the ability of this substance to suppress t...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2010.05.005

    authors： Nicholson RA,David LS,Pan RL,Liu XM

    更新日期：2010-10-01 00:00:00

  • New isocoumarins and alkaloid from Chinese insect medicine, Eupolyphaga sinensis Walker.

    abstract：:Two new isocoumarins (1 and 2), a new alkaloid (3), and a known N-acetyldopamine dimer (4) were isolated from the ethyl acetate extract of Chinese insect medicine Eupolyphaga sinensis. Their structures were elucidated on the basis of detailed spectroscopic investigations, such as 1D- and 2D NMR spectroscopy, as well a...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2012.06.005

    authors： Jiang HL,Luo XH,Wang XZ,Yang JL,Yao XJ,Crews P,Valeriote FA,Wu QX

    更新日期：2012-10-01 00:00:00

  • Sulfur-containing iridoid glucosides from Paederia scandens.

    abstract：:A new sulfur-containing iridoid glucoside, named paederoside B, was isolated from the stems of Paederia scandens. The structure of the new compound was elucidated as paederosidyl paederosidate by spectral evidence. ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2006.05.003

    authors： Zou X,Peng S,Liu X,Bai B,Ding L

    更新日期：2006-07-01 00:00:00

  • Two new lathyrane type diterpenoids from Euphorbia aellenii.

    abstract：:Euphorbia aellenii Rech. f. (Euphorbiaceae) afforded a cytotoxic chloroform fraction from which two new esters of 6(17)-epoxylathyrol were identified (1 and 2). The structure of these compounds was elucidated by spectroscopic methods. ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2010.05.017

    authors： Ayatollahi AM,Ghanadian M,Afsharypuor S,Choudhary MI,Kobarfard F,Rahmati M

    更新日期：2010-10-01 00:00:00

  • New findings on the in vivo antioxidant activity of Curcuma longa extract by an integrated (1)H NMR and HPLC-MS metabolomic approach.

    abstract：:Curcuminoids possess powerful antioxidant activity as demonstrated in many chemical in vitro tests and in several in vivo trials. Nevertheless, the mechanism of this activity is not completely elucidated and studies on the in vivo antioxidant effects are still needed. Metabolomics may be used as an attractive approach...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2015.12.013

    authors： Dall'Acqua S,Stocchero M,Boschiero I,Schiavon M,Golob S,Uddin J,Voinovich D,Mammi S,Schievano E

    更新日期：2016-03-01 00:00:00

  • Puerarin exhibits weak estrogenic activity in female rats.

    abstract：:A weak estrogenicity of puerarin on reproductive organs was addressed in female rats. In short-term treatment, immature ovariectomized rats were injected with 0.7 mg/kg BW/day of puerarin, for 14 days. Puerarin did not increase uterus weights, endometrium and myometrium areas, and the percent of cornified cells (%Co),...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2010.01.019

    authors： Malaivijitnond S,Tungmunnithum D,Gittarasanee S,Kawin K,Limjunyawong N

    更新日期：2010-09-01 00:00:00

  • Proteolytic activity in some Patagonian plants from Argentina.

    abstract：:Six Patagonian plants were screened for proteolytic activity: Colliguaja integerrima, Euphorbia collina, E. peplus and Stillingia patagonica (Euphorbiaceae), Philibertia gilliesii (Asclepiadaceae) and Grindelia chiloensis (Asteraceae). P. gilliesii extracts showed the highest specific activity, followed by S. patagoni...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/s0367-326x(03)00146-1

    authors： Sequeiros C,López LM,Caffini NO,Natalucci CL

    更新日期：2003-09-01 00:00:00

  • New tricyclic prezizaane sesquiterpenoids from agarwood.

    abstract：:Ten new tricyclic prezizaane types sesquiterpenoids (1-10) were isolated from ethyl ether extract of agarwood originated from Aquilaria sp. Their structures were unambiguously elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of the new prezizaenes 1, 2 and 4 was d...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2019.104301

    authors： Yang YL,Li W,Wang H,Yang L,Yuan JZ,Cai CH,Chen HQ,Dong WH,Ding XP,Jiang B,Mándi A,Kurtán T,Mei WL,Dai HF

    更新日期：2019-10-01 00:00:00

  • Metabolism mediated interaction of α-asarone and Acorus calamus with CYP3A4 and CYP2D6.

    abstract：:The present study was aimed to investigate the possible interaction of the standardized extract of Acorus calamus (AC) with Cytochrome P450 enzyme, quantitative determination of the α-asarone in the AC rhizome was performed by RP-HPLC method. In vitro interaction of the plant extract was evaluated by CYP450-carbon mon...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2010.11.009

    authors： Pandit S,Mukherjee PK,Ponnusankar S,Venkatesh M,Srikanth N

    更新日期：2011-04-01 00:00:00

  • Astershionones A-F, six new anti-HBV shionane-type triterpenes from Aster tataricus.

    abstract：:Six new shionane-type triterpenes, astershionones A-F (1-6), were obtained from the roots and rhizomes of Aster tataricus. Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data. The absolute configuration of 1 was determined by single crystal X-ray diffraction analysis and CD anal...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2013.12.021

    authors： Zhou WB,Zeng GZ,Xu HM,He WJ,Zhang YM,Tan NH

    更新日期：2014-03-01 00:00:00

  • A new abietane diterpenoid from Ajuga ovalifolia var. calantha induces human lung epithelial A549 cell apoptosis by inhibiting SHP2.

    abstract：:The Src-homology 2 domain-containing phosphatase 2 (SHP2), encoded by PTPN11, has been reported oncogenic tyrosine phosphatase associated with various tumors and played critical roles in many cell signaling events. Targeting SHP2 by small molecules may be a promising way for cancer therapy. Herein, a new abietane dite...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2020.104484

    authors： Liu DM,Cao ZX,Yan HL,Li W,Yang F,Zhao WJ,Diao QC,Tan YZ

    更新日期：2020-03-01 00:00:00

  • Atranones from Stachybotrys chartarum and their antitumor activities in MG-63 human osteosarcoma cells.

    abstract：:Two new atranones T and U (1 and 2), and three known analogues atranone B (3), atranone Q (4), and stachatranone C (5) were isolated from the toxigenic fungus Stachybotrys chartarum. Their structures and absolute configurations were elucidated by spectroscopic data and calculated ECD analyses. The cytotoxicities of al...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2020.104727

    authors： Qin YD,Fang FM,Zhou JJ,Wang RB,Xu SX,Li LH,Zhang HL

    更新日期：2020-10-01 00:00:00

  • Two new diterpenoids and other constituents from Isodon rubescens.

    abstract：:Two new ent-kaurene diterpenoids, 15α-acetoxyl-6,11α-epoxy-6α-hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7-olide (1), 15α-hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (2), together with ten known compounds (5-14) were isolated from the leaves of Isodon rubescens. Their structures were elucidated mainly by ...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2011.03.003

    authors： Xie RJ,Yan FL,Hai GF,Hou RJ,Ding MM,Bai YX

    更新日期：2011-06-01 00:00:00

  • Caffeoylserotonin suppresses THP-1 monocyte adhesion and migration via inhibition of the integrin β1/FAK/Akt signalling pathway.

    abstract：:We investigated the effect of caffeoylserotonin (CaS) on THP-1 monocyte migration and adhesion to fibronectin in response to MCP-1. CaS decreased monocyte adhesion and migration induced by MCP-1, together with CCR2 expression and α5β1 integrin, and activated β1 integrin expression on the cell surface. CaS also inhibit...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2012.04.025

    authors： Yoon JH,Kim HE,Choi JY,Bae HJ,Lee SG

    更新日期：2012-12-01 00:00:00

  • Possible clues for camptothecin biosynthesis from the metabolites in camptothecin-producing plants.

    abstract：:The plant derived camptothecin (CPT) is a pentacyclic pyrroloquinoline alkaloid with unique antitumor activity. Successive discoveries of new CPT-producing plants occurred in recent years due to market demands. The scattered distribution among angiosperms drew researchers' attention. The aim of this review is to appra...

    journal_title：Fitoterapia

    pub_type： 杂志文章,评审

    doi：10.1016/j.fitote.2019.02.014

    authors： Pu X,Zhang CR,Zhu L,Li QL,Huang QM,Zhang L,Luo YG

    更新日期：2019-04-01 00:00:00

  • Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells.

    abstract：:StAPs are potato aspartic proteases with cytotoxic activity against plant pathogens and spermatozoa. StAPs cytotoxic activity is selective, since these proteins do not exert toxic effect on plant cells and erythrocytes. In this work, we investigated the capacity of StAPs to exert cytotoxicity on human leukaemia cells....

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2009.10.004

    authors： Mendieta JR,Fimognari C,Daleo GR,Hrelia P,Guevara MG

    更新日期：2010-07-01 00:00:00

  • Ursene type nortriterpene from Debregeasia salicifolia.

    abstract：:A new triterpene, 3beta-19alpha-dihydroxy-30-norurs-12-ene (1), has been isolated from the methanolic extract of Debregeasia salicifolia stems. Its structure has been elucidated with the help of one- and two-dimensional NMR and NOE studies. Lupeol, beta-sitosterol, stigmasterol and oleanolic acid are also reported for...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/s0367-326x(00)00338-5

    authors： Akbar E,Riaz M,Malik A

    更新日期：2001-05-01 00:00:00

  • Acylphloroglucinol and tocotrienol derivatives from the fruits of Garcinia paucinervis.

    abstract：:Three undescribed polycyclic polyprenylated acylphloroglucinols (PPAPs) and three tocotrienols derivatives, named as paucinochymol A-F (1-3 and 10-12), together with six known PPAPs, were isolated from the fruits of Garcinia paucinervis. Their structures and absolute configurations were determined by extensive NMR ana...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2020.104688

    authors： Tan X,Zhong F,Teng H,Li Q,Li Y,Mei Z,Chen Y,Yang G

    更新日期：2020-10-01 00:00:00

  • Five novel naphthylisoquinoline alkaloids with growth inhibitory activities against human leukemia cells HL-60, K562 and U937 from stems and leaves of Ancistrocladus tectorius.

    abstract：:Two new 7,6'-coupled naphthylisoquinolines, namely ancistrotectorines A (1) and B (2), two new 5,3'-coupled naphthylisoquinolines, namely ancistrotectorines C (3) and D (4), and one new 7,8-coupled naphthylisoquinoline, namely ancistrotectorine E (5), together with 9 known naphthylisoquinoline alkaloids, hamatine (6),...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2013.09.010

    authors： Jiang C,Li ZL,Gong P,Kang SL,Liu MS,Pei YH,Jing YK,Hua HM

    更新日期：2013-12-01 00:00:00

  • Five new benzylphenanthrenes from Cremastra appendiculata.

    abstract：:Five new benzylphenanthrenes, cremaphenanthrenes L-P (1-5) were isolated from the EtOAc-soluble extract of the tubers of Cremastra appendiculata. Their structures were elucidated based on the spectroscopic data and chemical methods. Compounds 1-5 were tested in vitro for their cytotoxic effects against colon (HCT-116)...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2015.03.003

    authors： Liu L,Li J,Zeng KW,Jiang Y,Tu PF

    更新日期：2015-06-01 00:00:00

  • Glomerxanthones A-C, three xanthonolignoid C-glycosides from Polygala glomerata Lour.

    abstract：:Three novel xanthonolignoid C-glycosides, glomexanthones A-C, with a trans-dihydrobenzofuran on B ring and a 2-hydroxymethyl-5-hydroxyl-2-pentenoic acid moiety in the sugar chain were isolated from an ethanol extract of Polygala glomerata. Their structures and absolute configurations were characterized by extensive NM...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2013.12.009

    authors： Li CJ,Yang JZ,Yu SS,Zhao CY,Peng Y,Wang XL,Zhang DM

    更新日期：2014-03-01 00:00:00

  • Regeneration, in vitro glycoalkaloids production and evaluation of bioactivity of callus methanolic extract of Solanum tuberosum L.

    abstract：:Callus and differentiated shoots initiated from Solanum tuberosum L. on MS media containing BA, IAA, and Kin. Glycoalkaloids are produced in callus and shoots in concentrations higher than original tubers using HPLC. Callus methanolic extract had promising anticancer activity with low IC(50) values against human carci...

    journal_title：Fitoterapia

    pub_type： 杂志文章

    doi：10.1016/j.fitote.2010.03.001

    authors： Al-Ashaal HA

    更新日期：2010-09-01 00:00:00