Abstract:
:Five new benzylphenanthrenes, cremaphenanthrenes L-P (1-5) were isolated from the EtOAc-soluble extract of the tubers of Cremastra appendiculata. Their structures were elucidated based on the spectroscopic data and chemical methods. Compounds 1-5 were tested in vitro for their cytotoxic effects against colon (HCT-116), cervix (Hela), and breast (MCF-7 and MDA-MB-231) cancer cell lines. Compound 1 showed moderate cytotoxic activities against HCT-116, MCF-7, and MDA-MB-231 cancer cell lines with IC50 values ranging from 15.84 to 24.18 μM and weak cytotoxicity to Hela cell line with IC50 value of 68.81 μM.
journal_name
Fitoterapiajournal_title
Fitoterapiaauthors
Liu L,Li J,Zeng KW,Jiang Y,Tu PFdoi
10.1016/j.fitote.2015.03.003subject
Has Abstractpub_date
2015-06-01 00:00:00pages
27-32eissn
0367-326Xissn
1873-6971pii
S0367-326X(15)00057-Xjournal_volume
103pub_type
杂志文章相关文献
FITOTERAPIA文献大全abstract::Psychotria is a complex genus whose neotropical species are known by the presence of glucosidic monoterpene indole alkaloids. These compounds are able to display a large range of effects on the central nervous system, such as anxiolytic, antidepressant, analgesic, and impairment of learning and memory acquisition. The...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2012.04.013
更新日期:2012-09-01 00:00:00
abstract::Cyclotides describe a unique cyclic peptide family that displays a broad range of biological activities including uterotonic, anti-bacteria, anti-cancer and anti-HIV. The vigno cyclotides consist of vigno 1-10 were reported recently from Viola ignobilis. In the present study, we examined the effects of vigno 5, a natu...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2015.12.021
更新日期:2016-03-01 00:00:00
abstract::There is growing evidence that motherwort (Leonurus japonicus Houtt.), and Chinese patent medicines derived from motherwort, alleviate postpartum uterine subinvolution, as well as the effects on myocardial and cerebral ischemic injuries. We hypothesized that these beneficial effects of motherwort may be related to ang...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2018.05.002
更新日期:2018-07-01 00:00:00
abstract::A new triterpene glycoside (1) along with the known intercedenside B (2) was isolated from the sea cucumber Pseudocolochirus violaceus. Glycoside 1 was elucidated as 3-O-{6-O-sodiumsulfate-3-O-methyl-beta-D-glucopyranosyl-(1-->3)-beta-D-xylopyranosyl-(1-->4)-[beta-D-xylopyranosyl(1-->2)]-beta-D-quinovopyranosyl-(1-->2...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2007.02.010
更新日期:2007-06-01 00:00:00
abstract::Two new atranones T and U (1 and 2), and three known analogues atranone B (3), atranone Q (4), and stachatranone C (5) were isolated from the toxigenic fungus Stachybotrys chartarum. Their structures and absolute configurations were elucidated by spectroscopic data and calculated ECD analyses. The cytotoxicities of al...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2020.104727
更新日期:2020-10-01 00:00:00
abstract::Chemical investigation of the liquid culture of the endophytic fungus Bipolaris sorokiniana A606, which was isolated from the medicinal plant Pogostemon cablin resulted in the isolation of four new cytotoxic compounds, named isocochlioquinones D-E (1-2) and cochlioquinones G-H (3-4), along with five known cochlioquino...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2016.02.005
更新日期:2016-04-01 00:00:00
abstract::Combinations of thyme, cowslip and liquorice roots are often used in the treatment of upper respiratory tract infections. Therefore the volatile fraction of herbal teas prepared from thyme (Thymus vulgaris) and the effect of combining with cowslip (Primula veris/P. elatior) and liquorice roots (Glycyrrhiza glabra) on ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2011.05.006
更新日期:2011-09-01 00:00:00
abstract::Extracts of Lantana camara var. aculeata leaves were studied for their phytochemical constituents and termiticidal effects against adult termite workers. The 5% chloroform extract was found to be significantly effective against termite workers. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2006.05.014
更新日期:2006-09-01 00:00:00
abstract::The objective of this study was to evaluate potential hepatoprotective capabilities of quercetin in relation to its modulation of the HO-1 and NOS-2 activities in an experimental model of fulminant liver failure. Liver insult was induced by in vivo administration of D-galactosamine (d-GalN, 400 mg/kg, i.p.) and lipopo...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2013.03.016
更新日期:2013-06-01 00:00:00
abstract::Six new monoterpenoid indole alkaloids, 19(E)-9-demethoxy-16-dehydroxylchitosenine-17-O- β-d-glucopyranoside (1), 19(E)-9,10-didemethoxy-16-dehydroxylchitosenine-17-O-β-d-gluco-pyranoside (2), 19(E)-9,10-didemethoxy-16-dehydroxyl-11-methoxychitosenine (3), 19(E)-9,10-didemethoxy-16-dehydroxyl-11-methoxychitosenine-17-...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2017.09.017
更新日期:2018-01-01 00:00:00
abstract::Five new koumine-type alkaloids (1-5) along with six known ones were isolated from the roots of Gelsemium elegans. Their structures with absolute configurations were elucidated on the basis of NMR spectroscopy and electronic circular dichroism spectral analyses. The inhibitory effects of compounds 1-11 on the viabilit...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2017.03.004
更新日期:2017-04-01 00:00:00
abstract::Five rare dichloro aromatic polyketides (1-5) were obtained from an endophytic fungus Penicillium sp., along with five known metabolites (6-10). Their structures were elucidated by extensive spectroscopic analysis, Mosher methods, as well as [Rh2(OCOCF3)4]-induced electronic circular dichroism (ECD) experiments. Compo...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2016.11.008
更新日期:2017-01-01 00:00:00
abstract::Two spiro paclitaxel-mimics consisting only of an oxetane D-ring and a C-13 side chain were designed and synthesized on the basis of analysis of structure-activity relationships (SAR) of paclitaxel. In vitro microtubule-stabilizing and antiproliferative assays indicated a moderate weaker activity of the mimics than pa...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2013.10.015
更新日期:2014-01-01 00:00:00
abstract::Ethanol extract of Maytenus rigida stem bark and its fractions were assessed for antinociceptive activity in tail-flick test in rats. The activity was located in the chloroform, ethyl acetate and aq.methanol fractions. Phytochemical screening revealed that catechin was the only common class of compounds present on the...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2007.02.017
更新日期:2007-12-01 00:00:00
abstract::The cytotoxic effects of seven constituents isolated from Duguetia glabriuscula were evaluated against Hep2 human larynx carcinoma cells. The cytotoxicity exhibited by beta-sitosterol was as strong as that of cis-platin. (+)-Alloaromadendran-10,14beta-diol caused inhibition of cellular growth with IC50 values lower th...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2006.01.013
更新日期:2006-04-01 00:00:00
abstract::Isonuatigenin-3-O-beta-solatriose (1) was isolated from the roots of Solanum sisymbriifolium. Its structure was determined by spectroscopic methods. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2005.04.008
更新日期:2005-09-01 00:00:00
abstract::This investigation focuses on the in vitro neuroactive properties of pinostrobin, a substituted flavanone from Cajanus cajan (L.) Millsp. of the Fabaceae family. We demonstrate that pinostrobin inhibits voltage-gated sodium channels of mammalian brain (IC(50)=23 µM) based on the ability of this substance to suppress t...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2010.05.005
更新日期:2010-10-01 00:00:00
abstract::Bioassay-guided fractionation of the dichloromethane extract of the fungus Neofusicoccum austral SYSU-SKS024 led to the isolation of three new ethylnaphthoquinone derivatives, neofusnaphthoquinone A (1), 6-(1-methoxylethy1)-2,7-dimethoxyjuglone (2), (3R,4R)-3-methoxyl-botryosphaerone D (6), together with six known ana...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2018.01.014
更新日期:2018-03-01 00:00:00
abstract::The fruit rind of Garcinia gummi-gutta, commonly known as Garcinia cambogia (syn.), is extensively used traditionally as a flavourant in fish curries due to its sharp sour taste. Additional ethnobotanical uses include its use as a digestive and a traditional remedy to treat bowel complaints, intestinal parasites and r...
journal_title:Fitoterapia
pub_type: 杂志文章,评审
doi:10.1016/j.fitote.2015.02.012
更新日期:2015-04-01 00:00:00
abstract::The present study was designed to verify whether frutalin (FTL) affords gastroprotection against the ethanol-induced gastric damage and to examine the underlying mechanism(s). Gastric damage was induced by intragastric administration of 0.2 ml of ethanol (96%). Mice in groups were pretreated with FTL (0.25, 0.5 and 1 ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2012.01.005
更新日期:2012-04-01 00:00:00
abstract::Four new taraxerane triterpenoids, 1β,3β-dihydroxy-11α,12α-oxidotaraxerane (1), 28-hydroxy-11α,12α-oxidotaraxerane-3-one (2), 3β-hydroxy-11α,12α-oxidotaraxerane-28-al (3), and 3-O-acetyl-11α,12α-oxidotaraxerane-28-al (4), together with three known compounds 3β-hydroxy-11α,12α-oxidotaraxerane (5), 3β,28-dihydroxy-11α,1...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2011.09.009
更新日期:2012-01-01 00:00:00
abstract::Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of 0.25-1mg/ml. It inhibited hydrol...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2010.07.002
更新日期:2010-12-01 00:00:00
abstract::Thirty four terpenoids, including two new cadinane-type sesquiterpenoids containing conjugated aromatic-ketone moieties, curcujinone A (1) and curcujinone B (2), were isolated from 95% ethanol extract of the root tubers of Curcuma wenyujin. Their structures were determined by spectroscopic methods, especially 2D NMR a...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2017.06.011
更新日期:2017-09-01 00:00:00
abstract::Activity-guided fractionation of the methanol extract of Vitis vinifera bark led to the isolation of epsilon-viniferin, ampelopcin A, vitisin A and vitisin B. Vitisin A and vitisin B showed a remarkable inhibitory activity against 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) reductase with IC50 value of 42.1 microM...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2007.11.005
更新日期:2008-04-01 00:00:00
abstract::Three new secoiridoid aglycones of (-)-swermusic acid A (1) and B (3), and (-)-swerimuslatone A (2), and four new secoiridoid glycosides of 6'-O-formylsweroside (4), 6'-O-formylgentiopicroside (5), 6'-O-acetylamarogentin (6) and 6'-O-acetylamaronitidin (7), along with 40 known compounds (8-47) were isolated from Swert...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2015.01.020
更新日期:2015-04-01 00:00:00
abstract::Cinnamon is the dried bark of Cinnamomum cassia Presl, and its main component is cinnamaldehyde (CA). Decades of synthetic pesticide use to control parasitic nematodes that can harm plants has seriously polluted the environment and poses a risk to soil ecology, highlighting the need to develop natural biological pesti...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2020.104687
更新日期:2020-10-01 00:00:00
abstract::Euphorbia aellenii Rech. f. (Euphorbiaceae) afforded a cytotoxic chloroform fraction from which two new esters of 6(17)-epoxylathyrol were identified (1 and 2). The structure of these compounds was elucidated by spectroscopic methods. ...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2010.05.017
更新日期:2010-10-01 00:00:00
abstract::Wedelia (Sphagneticola trilobata, Syn. Wedelia trilobata), a notoriously invasive agricultural weed, can inhibit the growth and development of crops in the field. Eight new eudesmanolides (1-8), along with twelve known congeners (9-20), were isolated and identified from the flowers of Wedelia. Their chemical structure...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2019.104452
更新日期:2020-04-01 00:00:00
abstract::Two new triterpenoid estersaponins (1, 2) were isolated from the leaves of Pittosporum tobira 'Variegata' (Thunb.) W. T. Aiton, along with one known saponin (3) and one known flavonoid glycoside (4). Their structures were established by different spectroscopic methods including 1D and 2D NMR, UV, as well as ESI-MS ana...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2015.09.006
更新日期:2015-10-01 00:00:00
abstract::Diketopiperazine is a natural products found from bacteria, fungi, marine sponges, gorgonian and red algae. They are cyclic dipeptides possessing relatively simple and rigid structures with chiral nature and various side chains. The compounds in this structure class have been known to possess diverse bioactivities inc...
journal_title:Fitoterapia
pub_type: 杂志文章
doi:10.1016/j.fitote.2016.03.016
更新日期:2016-04-01 00:00:00